Modified human plasma polypeptide or Fc scaffolds and their uses
Modified human plasma polypeptides or Fc and uses thereof are provided.
1. A human serum albumin (HSA) comprising a non-naturally encoded amino acid at one of the following positions: 34, 82, 172, 301, 364, and 505 of SEQ ID NO:1, linked to one or more biologically active molecules selected from the group consisting of inhibin peptides, interleukin proteins, and interleukin receptor proteins.
2. The HSA of claim 1 , wherein the HSA comprises one or more post-translational modifications.
3. The HSA of claim 1 , wherein the interleukin proteins are selected from the group consisting of IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, and IL-12.
4. The HSA of claim 1 , wherein the interleukin receptor proteins are selected from the group consisting of IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, and IL-12, IL-13, IL-14, and IL-15 receptor proteins.