Flexible spirally-rolled polymer tube for monitoring and treatment of brain injuries

1. A flexible spirally-rolled polymer microtube for in vivo monitoring and treatment of brain injuries, the microtube integrally comprising one or more microsensors and one or more microchannels, wherein the microsensors monitor one or more parameters and the microchannels are capable of delivering substances to the brain and removing substances from the brain, and wherein the one or more microchannels is each from 1 μm to 2000 μm in length, width, and depth, and wherein each of the one or more microchannels has a microchannel interior, with each microchannel interior having at least two microchannel openings which are oriented perpendicular to a length along the longitudinal axis of the microchannel interior, wherein the microtube has an opening at each longitudinal end, and wherein the at least two microchannel openings extend inwardly toward a central axis of the longitudinal length of the microtube and away from a polymer layer of the microtube.

2. The microtube according to claim 1 , wherein the microtube comprises one or more polymers selected from the group consisting of polyimide, poly(p-xylylene), and polyvinylidene fluoride trifluoroethylene (PDVF-TrFE).

3. The microtube according to claim 1 , wherein the micro sensors comprise one or more pressure sensors, pH sensors, temperature sensors, glucose sensors, oxygen sensors, lactate sensors, pyruvate sensors, glutamate sensors, or carbon dioxide sensors.

4. The microtube according to claim 1 , wherein one or more of the microsensors comprise amperometric, hot-wire anemometric, voltammetric, or potentiometric sensors.

5. The microtube according to claim 1 , wherein one or more of the microsensors comprise pressure sensors selected from the group consisting of piezoelectric,

piezoresistive, and capacitive pressure sensors.

6. The microtube according to claim 1 , wherein one or more of the microsensors comprise temperature sensors selected from the group consisting of resistance temperature detectors and temperature sensitive resistors.

7. The microtube according to claim 1 , wherein one or more of the microsensors are fabricated on the exterior surface of the microtube.

8. The microtube according to claim 1 , wherein one or more of the microsensors are fabricated on the interior surface of the microtube.

9. The microtube according to claim 1 , wherein one or more of the microsensors are fabricated on the interior surface and one or more of the microsensors are fabricated on the exterior surface of the microtube.

10. The microtube according to claim 1 , wherein one or more of the microsensors are operatively coupled to a signal conditioning device, a data acquisition device, or both.

11. The microtube according to claim 1 , wherein one or more of the microsensors are operatively coupled to a data acquisition device operating multimodality monitoring software.

12. The microtube according to claim 1 , wherein the data obtained by the microsensors is monitored in real time, continuously, or both.

13. The microtube according to claim 1 , wherein one or more of the microchannels are fabricated on the exterior surface of the microtube.

14. The microtube according to claim 1 , wherein the at least two microchannel openings are from two to four microchannel openings.

15. The microtube according to claim 1 , wherein one or more of the microchannels are fabricated on the interior surface and one or more of the microchannels are fabricated on the exterior surface of the microtube.

16. The microtube according to claim 1 , wherein one or more of the microchannels have a plurality of inlets, a plurality of outlets, or a plurality of both inlets and outlets.

17. The microtube according to claim 1 , wherein one or more of the microchannels is capable of performing convection-enhanced delivery of substances to the brain.

18. The microtube according to claim 1 , wherein one or more of the microchannels is in fluid communication with one or more dose control systems, drainage bags, or reservoirs.

19. The microtube according to claim 1 , wherein the microtube is located or attached at or near the end of a stylet, needle, endoscope, or catheter.

20. The microtube according to claim 1 , wherein the substances delivered to the brain and the substances removed from the brain are selected from the group consisting of drugs, chemicals, genes, cells, and calibrated buffer solution.

21. The microtube according to claim 20 , wherein the substances delivered to the brain consists of the calibrated buffer solution for in situ calibration of the one or more microsensors.

22. A flexible spirally-rolled polymer microtube for in vivo monitoring and treatment of brain injuries, the microtube integrally comprising glucose, oxygen, temperature, and pressure microsensors and two or more microchannels, wherein the two or more microchannels are capable of delivering substances to the brain and removing substances from the brain, and wherein the two or more microchannels are each from 1 μm to 2000 μm in length, width, and depth and wherein each of the two or more microchannels has a rectangular microchannel interior having at least two microchannel openings, with each microchannel opening being oriented perpendicular to a length along the longitudinal axis of the microchannel interior, wherein the substances delivered to the brain and the substances removed from the brain are minute volumes of liquids or gases, wherein the microtube has an opening at each longitudinal end, and wherein the at least two microchannel openings extend inwardly toward a central axis of the longitudinal length of the microtube and away from a polymer layer of the microtube.