Drug cores for sustained release of therapeutic agents
A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.
1. A method of manufacturing a drug insert for an implant body adapted for disposition within or adjacent to a body cavity, tissue, duct or fluid of a patient, the method comprising injecting into a precursor sheath body, at an extrusion temperature of less than about 15° C., a mixture comprising latanoprost and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the latanoprost,
curing the mixture, at a curing temperature greater than about 25° C., in the precursor sheath body to provide a cured, filled precursor sheath body containing a precursor drug core; and
dividing the cured filled precursor sheath body to form a plurality of drug inserts, wherein the drug inserts comprise inclusions of the latanoprost with an average diameter of less than about 10 μm.
2. The method of claim 1 , wherein each of the plurality of drug inserts is of substantially the same length, and wherein an amount of the latanoprost in a first insert of the plurality is similar to the amount of agent in any other insert of the plurality.
3. The method of claim 1 , wherein the implant is adapted for disposition in or adjacent to an eye of a patient.
4. The method of claim 1 , wherein the amount of the latanoprost in a volumetric portion of the cured mixture varies from the amount of the latanoprost in any other equal volumetric portion of the cured mixture by no greater than about 10%.
5. The method of claim 1 , wherein the amount of the latanoprost in a volumetric portion of the cured mixture varies from the amount of the latanoprost in any other equal volumetric portion of the cured mixture by no greater than about 5%.
6. The method of claim 1 , wherein the amount of the latanoprost in each of the plurality of drug inserts varies by no greater than about 10% therebetween.
7. The method of claim 1 , wherein the amount of the latanoprost in each of the plurality of drug inserts varies by no greater than about 5% therebetween.
8. The method of claim 1 , wherein said dividing the cured filled precursor sheath body comprises cutting the cured filled precursor sheath body with a blade or with a laser.
9. The method of claim 1 , wherein the implant body comprises a punctal plug adapted to be disposed within the punctum of the patient.
10. The method of claim 1 , wherein said curing comprises placing the precursor sheath body in a humidity chamber, heating, or vacuum treatment.
11. The method of claim 1 , wherein said curing the mixture comprises heating the mixture to the curing temperature, at a relative humidity, for a period of time.
12. The method of claim 11 , wherein the curing temperature is in a range from about 25° C. to about 100° C., the relative humidity is in a range from about 30% to about 100%, and the period of time is in a range from about 1 minute to about 48 hours.
13. The method of claim 12 , wherein the curing temperature is at least about 40° C., or the relative humidity is at least about 80%, or both.
14. The method of claim 1 , wherein said injecting comprises injecting under a pressure of at least about 40 psi.
15. The method of claim 1 , wherein the extrusion temperature is in a range of about −50° C. to about 15° C.
16. The method of claim 15 , wherein the extrusion temperature is in a range of about −10° C. to about 10° C.
17. The method of claim 1 , wherein the mixture is injected such that the precursor sheath body is filled at a rate of no greater than about 0.5 cm/sec.
18. The method of claim 1 , further comprising sealing each drug insert at one end thereof, a second end providing the exposed surface.
19. The method of claim 18 , wherein each drug insert is sealed at one end thereof with a UV-curable adhesive, a cyanoacrylate, an epoxy, by pinching, with a heat weld, or with a cap.
20. The method of claim 19 , further comprising irradiating the drug insert with a UV-curable adhesive with UV light.
21. The method of claim 19 , further comprising, after sealing one end thereof, inserting each drug insert into a channel of an implant body adapted to receive the insert therein.
22. The method of claim 1 , wherein the insert comprises about 0.1 wt % to about 50 wt % of the latanoprost.
23. The method of claim 1 , wherein the precursor sheath body comprises at least one of polyimide, PMMA, PET, stainless steel, or titanium.
24. The method of claim 1 , wherein the latanoprost is dispersed within the silicone as droplets thereof.
25. The method of claim 1 , wherein the extrusion temperature comprises a temperature of less than about 10° C.
26. The method of claim 1 , wherein the extrusion temperature comprises a temperature of less than about 5° C.
27. A method for manufacturing a punctual plug, the method comprising:
injecting into a precursor sheath body, at an extrusion temperature of less than about 15° C., a mixture comprising latanoprost and a silicone matrix such that the precursor sheath body is substantially filled therewith, the precursor sheath body being substantially impermeable to the latanoprost,
curing the mixture, at a curing temperature greater than about 25° C., in the precursor sheath body to provide a cured, filled precursor sheath body containing a precursor drug core;
dividing the cured filled precursor sheath to form a plurality of drug inserts;
sealing each drug insert at one end of the drug insert; and
inserting each drug insert into a channel of an implant body adapted to receive the insert therein, wherein the drug inserts comprise inclusions of the latanoprost with an average diameter of less than about 10 μm.