System and method for dynamically adjusting patient therapy
A system and method of managing therapy provided to patients in an institution. The system monitors all aspects of the medication delivery to a patient, as well as other information related to the patient, such as values of vital signs, laboratory results and patient factors such as history, diagnosis, allergies and the like. The system includes one or more databases of information, including institutionally developed rules, guidelines and protocol representing the best medical practices of the institution. The system provides alerts and/or recommendations based on the application of the rules to the information being monitored, and alerts care givers accordingly, providing for dynamic adjustment of the patient's therapy. The system also monitors the status of the alerts, and if no action is taken in a selected period of time, may escalate the priority of the alert and/or halt the delivery of medication to the patient until the alert is resolved.
1. A system for managing therapy provided to a patient, comprising:
a memory comprising:
a pharmacodynamic (PD) model configured to predict a physiological response based on a concentration of a medication in the patient's body tissues; and
at least one limit for the physiological response; and
a processor coupled to the memory, the processor configured to:
receive a measured medication concentration of the medication within at least a portion of the patient's body tissue and a measured physiological response of the patient;
retrieve the PD model and the at least one limit from the memory;
utilize the PD model with the measured medication concentration to calculate a predicted physiological response of the patient; and
provide an alert if a difference between the predicted physiological response and the measured physiological response is outside the at least one limit.
2. The system of claim 1 , wherein the processor is further configured to provide an alert if the measured physiological response has not been received within a specified time frame since receipt of an immediately prior measured physiological response.
3. The system of claim 1 , wherein the processor is further configured to provide a recommendation for adjusting a rate of medication delivery to achieve a desired change in the physiological response.
4. The system of claim 1 , wherein the processor is further configured to provide a recommendation for adjusting a rate of medication delivery to achieve a desired target physiological response.
5. The system of claim 1 , further comprising a two-way communication system coupled between the memory and the processor.
6. A method of managing therapy provided to a patient, comprising the steps of:
receiving a measured medication concentration of a medication within at least a portion of a patient's body tissue and a measured physiological response of the patient;
retrieving a pharmacodynamic (PD) model and at least one limit for the physiological response from a memory, the PD model being configured to predict a physiological response based on a concentration of a medication in a patient's body tissues;
calculating a predicted physiological response of the patient automatically utilizing the PD model with the measured medication concentration; and
providing an alert automatically if a difference between the predicted physiological response and the measured physiological response is outside the at least one limit.
7. The method of claim 6 , further comprising the step of providing an alert automatically if the measured physiological response has not been received within a specified time frame since receipt of an immediately prior measured physiological response.
8. The method of claim 6 , further comprising the step of providing a recommendation for adjusting a rate of medication delivery to achieve a desired change in the physiological response.
9. The method of claim 6 , further comprising the step of providing a recommendation for adjusting a rate of medication delivery to achieve a desired target physiological response.
10. The method of claim 6 , wherein the step of retrieving a PD model and at least one limit for the physiological response from a memory comprises retrieving the PD model and the at least one limit for the physiological response through a two-way communication system coupled to the memory.