IP Library › Granted Patent US 8,632,820
Granted Patent B2
US 8,632,820 · App. 13/244,294 · Granted Jan 21, 2014

Compositions for achieving a therapeutic effect in an anatomical structure

Inventors: Wouter E. Roorda (Palo Alto, CA); Stephen D. Pacetti (San Jose, CA)
Assignee: Abbott Cardiovascular Systems Inc.
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,632,820
App. No.
13/244,294
Granted
Jan 21, 2014
Kind
B2
Abstract

Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Claims (15)

1. A particle to form an embolus within a region of an anatomical lumen, comprising a water soluble polymeric substance, a counterion and a wax; wherein the particle forms the embolus within the region for a transitory period and wherein the counterion comprises calcium, magnesium, barium, or a combination thereof.

2. The particle of claim 1 , wherein the water soluble polymeric substance comprises heparin, carboxymethylcellulose, alginates, polyethylene oxide, polyvinylpyrrolidone, or a combination thereof.

3. The particle of claim 1 , wherein the transitory period is less than seven days.

4. The particle of claim 1 , wherein the diameter of the particle is reduced or the particle disintegrates into fragments.

5. The particle of claim 1 , further comprising a therapeutic substance.

6. The particle of claim 5 , wherein the therapeutic substance is selected from the group consisting of antineoplastic, antiplatelet, anticoagulant, fibrinolytic, antimitotic, thrombin inhibitor, antiinflammatory, antiproliferative, antioxidant, antiangiogenic, angiogenic, arteriogenic and antiallergic substances, and mixtures thereof.

7. The particle of claim 1 , wherein the counterion comprises magnesium.

8. The particle of claim 1 , wherein the water soluble polymeric substance comprises carboxymethylcellulose, polyethylene oxide, polyvinylpyrrolidone, or a combination thereof.

9. The particle of claim 1 , wherein the water soluble polymeric substance comprises carboxymethylcellulose.

10. The particle of claim 1 , wherein the wax is a partially hydrogenated vegetable oil.

11. The particle of claim 1 , wherein the wax is a triglyceride.

12. The particle of claim 1 , wherein the wax is beeswax.

13. The particle of claim 1 , wherein the wax is a saturated fatty acid.

14. The particle of claim 1 , wherein the wax is a fatty acid ester.

15. The particle of claim 1 , wherein the wax is a phospholipid.

Continuity (4)
Continuation 12198749 · Aug 26, 2008
Division 11015943 · Dec 17, 2004
Division 09781599 · Feb 12, 2001
Related Publication 20120035107A1 · Feb 9, 2012