Treating multiple system atrophy with hMSC
The present invention provides a method for treating multiple system atrophy, comprising administering a therapeutically effective amount of mesenchymal stem cells (MSCs) to a human in need thereof. Preferably, the administering is performed by an intra-arterial injection of said MSCs and one or more intravenous injections of said MSCs.
1. A method for treating multiple system atrophy, comprising administering a therapeutically effective amount of mesenchymal stem cells (MSCs) to a human in need thereof, wherein said MSCs are autologous human mesenchymal stem cells.
2. The method according to claim 1 , wherein the administering is performed by an intra-arterial injection of said MSCs and one or more intravenous injections of said MSCs.
3. The method according to claim 2 , wherein the intra-arterial injection is performed by infusing MSCs into a bilateral internal carotid artery and/or into a dominant vertebral artery.
4. The method according to claim 3 , wherein the intra-arterial injection is performed by infusing about 2×10 7 MSCs into a bilateral internal carotid artery and about 2×10 7 MSCs into a dominant vertebral artery for about 60 minutes.
5. The method according to claim 2 , wherein the intravenous injections are consecutively performed every month, beginning 1 month after the intra-arterial injection.
6. The method according to claim 5 , wherein the intravenous injections are consecutively performed every month for 3 months, beginning 1 month after the intra-arterial injection.
7. The method according to claim 5 or 6 , wherein each intravenous injection is performed by infusing about 4×10 7 MSCs into an antecubital vain for about 30 minutes.