Prostamides for the treatment of glaucoma and related diseases
Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.
1. A compound consisting of an amide related to a prostaglandin and a biogenic amine, wherein said compound is not naturally occurring, and wherein said compound has the structure:
or a salt, or ester, thereof,
wherein
the hatched wedge indicates an α configuration and the solid wedge indicates a β configuration;
A and B are both CHOH;
R 1 is phenyl, indolyl, or monohydroxy or dihydroxy derivatives of phenyl or indolyl;
R 2 is OH or H;
R 3 is n-butyl, n-pentyl, or n-hexyl; and
R 4 is hydrogen, methyl, ethyl, iso-propyl, or n-propyl.
2. The compound of claim 1 of the structure
3. A compound of the structure: