System for providing flow-targeted ventilation synchronized to a patient's breathing cycle
An open system provides breath-synchronized, flow-targeted ventilation to augment respiration by a self-breathing patient. A sensor detects a physical property of a patient's respiratory cycle. A processor monitors the sensor and controls a gas source to deliver oxygen-containing gas through a tube extending into the patient's airway with the flow rate varying over each respiratory cycle in a predetermined non-constant waveform synchronized with the respiratory cycle to augment the patient's spontaneous respiration. Gas is delivered at a flow rate sufficient to significantly mitigate the airway pressure the patient must generate during spontaneous breathing and thereby reduce the patient's work of breathing.
1. A method for delivering a flow of oxygen-containing gas to the airway of a spontaneously-breathing patient with obstructive sleep apnea, said method comprising:
providing a tube to deliver a flow of oxygen-containing gas into a patient's airway without interfering with a patient's spontaneous respiration around the tube;
detecting a physical property of a patient's respiratory cycle; and
supplying a flow of oxygen-containing gas to augment the patient's spontaneous respiration, said flow varying over each inspiratory and expiratory phase of the respiratory cycle in a predetermined non-constant flow waveform synchronized with the respiratory cycle, said waveform including:
(a) a positive flow accelerating at the onset of the patient's inspiratory phase at a flow rate sufficient to at least partially prevent obstruction of the upper airway during obstructive sleep apnea, thereby significantly mitigating the airway pressure the patient must generate during spontaneous breathing and reducing the patient's work of breathing; and
(b) a positive flow during at least the early portion of the patient's expiratory phase at a flow rate sufficient to at least partially prevent obstruction of the upper airway during obstructive sleep apnea, thereby significantly mitigating the airway pressure the patient must generate during spontaneous breathing, reducing the patient's work of breathing, and washing carbon dioxide from the patient's airway.
2. The method of claim 1 wherein the tube comprises a nasal cannula.
3. The method of claim 1 wherein the tube comprises a transtracheal catheter.
4. The method of claim 1 wherein the tube comprises a nasopharyngeal catheter.
5. The method of claim 1 wherein the patient's respiratory cycle is detected by a pressure transducer.
6. The method of claim 1 wherein the patient's respiratory cycle is detected by a flow sensor.
7. The method of claim 1 wherein the patient's respiratory cycle is detected by a thermistor.
8. The method of claim 1 wherein the patient's respiratory cycle is detected by a carbon dioxide sensor.
9. An apparatus for delivering a flow of oxygen-containing gas to the airway of a spontaneously-breathing patient with obstructive sleep apnea, said apparatus comprising:
a tube delivering a flow of oxygen-containing gas into a patient's airway without interfering with a patient's spontaneous respiration around the tube;
a gas source delivering a variable flow of oxygen-containing gas through the tube;
a sensor detecting a physical property of a patient's respiratory cycle; and
a processor monitoring the sensor and controlling the gas source to deliver a flow of oxygen-containing gas through the tube to augment the patient's spontaneous respiration, said flow varying over each inspiratory and expiratory phase of the respiratory cycle in a predetermined non-constant flow waveform synchronized with the respiratory cycle, said waveform including:
(a) a positive flow accelerating at the onset of the patient's inspiratory phase at a flow rate sufficient to at least partially prevent obstruction of the upper airway during obstructive sleep apnea, thereby significantly mitigating the airway pressure the patient must generate during spontaneous breathing and reducing the patient's work of breathing; and
(b) a positive flow during at least the early portion of the patient's expiratory phase at a flow rate sufficient to at least partially prevent obstruction of the upper airway during obstructive sleep apnea, thereby significantly mitigating the airway pressure the patient must generate during spontaneous breathing, reducing the patient's work of breathing, and washing carbon dioxide from the patient's airway.
10. The apparatus of claim 9 wherein the sensor comprises a pressure transducer.
11. The apparatus of claim 9 wherein the sensor comprises a flow sensor.
12. The apparatus of claim 9 wherein the sensor comprises a thermistor.
13. The apparatus of claim 9 wherein the sensor comprises a carbon dioxide sensor.
14. The apparatus of claim 9 wherein the tube comprises a nasal cannula.
15. The apparatus of claim 9 wherein the tube comprises a transtracheal catheter.
16. The apparatus of claim 9 wherein the tube comprises a nasopharyngeal catheter.
17. The apparatus of claim 9 wherein the oxygen-containing gas is humidified.
18. The apparatus of claim 9 wherein the oxygen-containing gas is heated.
19. The apparatus of claim 9 wherein the oxygen-containing gas comprises air.
20. The apparatus of claim 9 wherein the oxygen-containing gas comprises oxygen-enriched air.