IP Library › Granted Patent US 8,653,268
Granted Patent B2
US 8,653,268 · App. 13/739,442 · Granted Feb 18, 2014

6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors

Inventors: Mark J. Mulvihill (Dix Hills, NY); Radoslaw Laufer (Ontario, CA); An-Hu Li (Commack, NY); Arno G. Steinig (E. Northport, NY)
Assignee: OSI Pharmaceuticals, LLC
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Quick Facts
Patent No.
US 8,653,268
App. No.
13/739,442
Granted
Feb 18, 2014
Kind
B2
Abstract

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , R 1 , and Q 1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

Claims (4)

1. A compound of the formula II-Z:

wherein A 11 is halo; and

R 1 is

wherein G 11a is methyl and G 11b is —OH, or G 11a and G 11b together define oxo.

Continuity (6)
Division 13308694 · Dec 1, 2011
Division 12540047 · Aug 12, 2009
Division 12244947 · Oct 3, 2008
Continuation 11095162 · Mar 31, 2005
Provisional Application 60559250 · Apr 2, 2004
Related Publication 20130190496A1 · Jul 25, 2013