IP Library › Granted Patent US 8,658,767
Granted Patent B2
US 8,658,767 · App. 13/296,617 · Granted Feb 25, 2014

Lipidated polyepitope vaccines

Inventors: Chih-Hsiang Leng (Zhunan Town, TW); Chi-Ling Tseng (Zhunan Town, TW); Hsueh-Hung Liu (Zhunan Town, TW); Shih-Jen Liu (Zhunan Town, TW); Hsin-Wei Chen (Zhunan Town, TW); Pele Choi-Sing Chong (Zhunan Town, TW)
Assignee: National Health Research Institutes
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,658,767
App. No.
13/296,617
Granted
Feb 25, 2014
Kind
B2
Abstract

This invention relates to, inter alia, an isolated lipidated polypeptide including a lipid moiety at the N-terminus and a plurality of epitopes, and methods of making and using the polypeptide.

Claims (9)

1. An isolated lipidated polypeptide comprising a lipid moiety at the N-terminus and a plurality of epitopes that includes YMLDLQPETT (SEQ ID NO:7), LLMGTLGIV (SEQ ID NO:8), FQQLFLNTL (SEQ ID NO:9), TLG1VCPI (SEQ ID NO: 10), TIHDIILECV (SEQ ID NO:11), and KCIDFYSRI (SEQ ID NO:12), wherein the polypeptide contains Ihe amino acid sequence of SEP ID NO:1 or 3.

2. The polypeptide of claim 1 , wherein the polypeptide includes the amino acid sequence of SEQ ID NO:1 or 3.

3. The polypeptide of claim 1 , wherein the polypeptide includes the amino acid sequence of SEQ ID NO:1.

4. The polypeptide of claim 2 , wherein the polypeptide includes the amino acid sequence of SEQ ID NO:4.

5. The polypeptide of claim 3 , wherein the polypeptide includes the amino acid sequence of SEQ ID NO:2.

6. A composition comprising the lipidated polypeptide of claim 1 .

7. A method of eliciting an immune response in a subject, the method comprising administering the composition of claim 6 to a subject in need thereof.

8. The method ol claim 7 , wherein the immune response is a CTL-mediated immune response.

9. A method of treating an HPV-associated disease, the method comprising administering the composition containing the lipidated polypeptide of claim 6 to a subject in need thereof.

Continuity (2)
Provisional Application 61413619 · Nov 15, 2010
Related Publication 20120121628A1 · May 17, 2012