Methods and apparatus for the planning and delivery of radiation treatments

1. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:

iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals over a preceding plurality of control points, the preceding plurality of control points located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and

upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points.

2. A method according to claim 1 wherein the at least one subsequent trajectory comprises a single trajectory that is the same as the preceding trajectory.

3. A method according to claim 1 wherein at least one of the at least one subsequent trajectory is the same as one or more of: the preceding trajectory;

and another of the at least one subsequent trajectory.

4. A method according to claim 1 wherein the at least one subsequent trajectory is different than the preceding trajectory during at least part of the iterative optimization over the increased plurality of control points.

5. A method according to claim 4 comprising permitting spatial variation of the increased plurality of control points to thereby optimize the at least one subsequent trajectory as part of the iterative optimization over the increased plurality of control points.

6. A method according to claim 1 wherein iteratively optimizing the simulated dose distribution relative to the set of one or more optimization goals over the increased plurality of control points comprises determining a set of radiation delivery parameters, the set of radiation delivery parameters specifying configurations of a multi-leaf collimator.

7. A method according to claim 6 wherein, for each of the increased plurality of control points, the configuration of the multi-leaf collimator comprises positions of one or more leaves of the multi-leaf collimator.

8. A method according to claim 1 wherein iteratively optimizing the simulated dose distribution over the preceding plurality of control points comprises modeling a dose distribution for at least one of the preceding plurality of control points, the modeling comprising:

dividing a cross-sectional area of a beam into a plurality of two-dimensional beamlets; and

simulating a dose distribution contribution from each of the plurality of two-dimensional beamlets.

9. A method according to claim 1 :

wherein iteratively optimizing the simulated dose distribution over the preceding plurality of control points comprises determining, for each of the preceding plurality of control points, a set of one or more radiation delivery parameters related to the delivery of radiation from the radiation source to the subject;

wherein prior to iteratively optimizing the simulated dose distribution over the increased plurality of control points, the method comprises, for one or more new control points that are included in the increased plurality of control points and not included in the preceding plurality of control points, assigning a set of one or more preceding radiation delivery parameters to the one or more new control points; and

wherein assigning the set of one or more preceding radiation delivery parameters to the one or more new control points comprises interpolating one or more corresponding radiation delivery parameters from the set of one or more radiation delivery parameters associated with the preceding plurality of control points.

10. A method according to claim 9 wherein interpolating the one or more corresponding radiation delivery parameters from the set of one or more radiation parameters associated with the preceding plurality of control points comprises, for each new control point among the one or more new control points, interpolating the one or more corresponding radiation delivery parameters associated with a pair of adjacent control points from among the preceding plurality of control points, the pair of adjacent control points located along the preceding trajectory at locations adjacent to either side of the new control point.

11. A method according to claim 1 comprising, prior to iteratively optimizing the simulated dose distribution over the increased plurality of control points, specifying one or more new control points included in the increased plurality of control points and not included in the preceding plurality of control points, each of the one or more new control points located along the preceding trajectory between a pair of adjacent preceding control points.

12. A method according to claim 1 wherein the preceding trajectory characterizes relative movement between the radiation source and the subject in three dimensions.

13. A method according to claim 1 wherein the preceding plurality of control points comprises two or more of the preceding plurality of control points at a same spatial location along the preceding trajectory.

14. A method according to claim 1 wherein the increased plurality of control points comprises two or more of the increased plurality of control points at a same spatial location along the at least one subsequent trajectory.

15. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:

iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals over a preceding plurality of control points, the preceding plurality of control points located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and

upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points

wherein:

the increased plurality of control points comprises two or more of the increased plurality of control points at a same spatial location along the at least one subsequent trajectory; and

a first of the two or more of the increased plurality of control points is from among both the increased plurality of control points and the preceding plurality of control points and a second of the two or more of the increased plurality of control points is from among the increased plurality of control points but not from among the preceding plurality of control points.

16. A method according to claim 1 comprising upon reaching one or more subsequent optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over a further increased plurality of control points, the further increased plurality of control points located along at least one further subsequent trajectory which characterizes relative movement between the radiation source and the subject and the further increased plurality of control points comprising a larger number of control points than the increased plurality of control points.

17. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:

iteratively optimizing a simulated dose distribution relative to a set of one of more optimization goals over a preceding plurality of control points;

wherein, prior to iteratively optimizing the simulated dose distribution over the preceding plurality of control points, the preceding plurality of control points are located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and

wherein iteratively optimizing the simulated dose distribution over the preceding plurality of control points comprises optimizing spatial locations of one or more of the preceding plurality of control points to thereby determine an optimized preceding trajectory.

18. A method according to claim 17 comprising:

continuing to iteratively optimize the simulated dose distribution over the preceding plurality of control points until reaching one or more preceding optimization termination conditions; and

upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points.

19. A method according to claim 18 wherein the at least one subsequent trajectory comprises a single trajectory that is the same as the optimized preceding trajectory.

20. A method according to claim 18 wherein iteratively optimizing the simulated dose distribution over the increased plurality of control point comprises optimizing spatial locations of one or more of the increased plurality of control points to thereby determine an optimized subsequent trajectory.