IP Library Granted Patent US 8,666,501
Granted Patent B2
US 8,666,501 · App. 13/673,764 · Granted Mar 4, 2014

Methods, systems, and devices for treating tinnitus with VNS pairing

Inventors: Michael P. Kilgard (Richardson, TX); Navzer Engineer (Plano, TX); David Michael Pierce (Plano, TX)
Assignees: MicroTransponder, Inc.; The Board of Regents, The University of Texas System
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Quick Facts
Patent No.
US 8,666,501
App. No.
13/673,764
Granted
Mar 4, 2014
Kind
B2
Abstract

A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

Claims (53)

1. A method of treating tinnitus comprising:

measuring a patient's hearing;

determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing;

programming a clinical controller with the measurements of the patient's hearing;

selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency;

setting an appropriate volume for each of the plurality of tones;

repetitively playing each of the plurality of therapeutic tones; and

pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

2. The method of claim 1 , further comprising a session including at least 100 tones per day.

3. The method of claim 1 , further comprising a session of 300 tones per day.

4. The method of claim 1 , wherein each therapeutic tone has a duration of about 500 milliseconds.

5. The method of claim 1 , wherein each vagus nerve stimulation pulse train has a duration of about 500 milliseconds.

6. The method of claim 1 , wherein the patient's hearing is measured by an audiologist.

7. The method of claim 1 , wherein the repetitive playing each of the plurality of therapeutic tones is random in time.

8. The method of claim 1 , wherein the repetitive playing each of the plurality of therapeutic tones selects the therapeutic tones frequencies randomly.

9. The method of claim 1 , wherein the therapeutic tones are pure tones.

10. The method of claim 1 , wherein each of the therapeutic tones is shaped by a ramp function.

11. The method of claim 1 , wherein each of the therapeutic tones is encoded with location data.

12. The method of claim 1 , wherein the selected therapeutic tones are at least a half-octave above the patient's tinnitus frequency.

13. The method of claim 1 , wherein the selected therapeutic tones are at least a half-octave below the patient's tinnitus frequency.

14. The method of claim 1 , wherein the selected therapeutic tones are at least a half-octave below the patient's tinnitus frequency.

15. A method of treating tinnitus comprising:

measuring a patient's hearing;

determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing;

programming a clinical controller with the measurements of the patient's hearing;

selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency;

setting an appropriate volume for each of the plurality of tones;

repetitively playing each of the plurality of therapeutic tones;

pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus; and

checking the volume level of each therapeutic tone.

16. A method of treating tinnitus comprising:

measuring a patient's hearing;

determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing;

programming a clinical controller with the measurements of the patient's hearing;

selecting a plurality of therapeutic tones where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency;

generating sound files by shaping the selected therapeutic tones using a ramp function;

modulating the sound files with phase information that simulates a sound source location;

setting an appropriate volume for each of the plurality of tones;

repetitively playing each of the plurality of therapeutic tones; and

pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.

17. The method of claim 16 , further comprising a session including at least 100 tones per day.

18. The method of claim 16 , further comprising a session of 300 tones per day.

19. The method of claim 16 , further comprising checking the volume level of each therapeutic tone.

20. The method of claim 16 , wherein each therapeutic tone has a duration of about 500 milliseconds.

21. The method of claim 16 , wherein each vagus nerve stimulation pulse train has a duration of about 500 milliseconds.

22. The method of claim 16 , wherein the patient's hearing is measured by an audiologist.

23. The method of claim 16 , wherein the repetitive playing each of the plurality of therapeutic tones is random in time.

24. The method of claim 16 , wherein the repetitive playing each of the plurality of therapeutic tones selects the therapeutic tones frequencies randomly.

25. The method of claim 16 , wherein the therapeutic tones are pure tones.

26. The method of claim 25 , wherein the repetitive playing each of the plurality of therapeutic tones is random in time.

27. The method of claim 25 , wherein the repetitive playing each of the plurality of therapeutic tones selects the therapeutic tones frequencies randomly.

28. The method of claim 16 , wherein each of the therapeutic tones is encoded with location data.

29. The method of claim 16 , wherein the selected therapeutic tones are at least a half-octave above the patient's tinnitus frequency.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2021
From: KILGARD, MICHAEL P.; ENGINEER, NAVZER D.; PIERCE, DAVID M.
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 057209/0316 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 2, 2016
From: MICROTRANSPONDER INC.
To: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 039315/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2014
From: KILGARD, MICHAEL
To: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 031982/0532 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2014
From: ENGINEER, NAVZER; PIERCE, DAVID
To: MICROTRANSPONDER, INC.
Reel/Frame 031982/0749 →
CONFIRMATORY LICENSE Recorded Sep 11, 2013
From: MICROTRANSPONDER, INC
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031201/0340 →
Continuity (12)
Continuation In Part 13095570 · Apr 27, 2011
Continuation In Part 12485040 · Jun 15, 2009
Provisional Application 61699470 · Sep 11, 2012
Provisional Application 61614369 · Mar 22, 2012
Provisional Application 61598185 · Feb 13, 2012
Provisional Application 61558287 · Nov 10, 2011
Provisional Application 61328621 · Apr 27, 2010
Provisional Application 61077648 · Jul 2, 2008
Provisional Application 61078954 · Jul 8, 2008
Provisional Application 61086116 · Aug 4, 2008
Provisional Application 61149387 · Feb 3, 2009
Related Publication 20130072996A1 · Mar 21, 2013