Compositions containing antibodies for treating CD5+ HLA-DR+ B or T cell related diseases
The present invention relates to compositions containing antibodies for treating CD5+ HLA-DR+ B OR T cell related diseases such as B or T cell malignances (leukaemia and lymphoma), autoimmune diseases and T cell related diseases as transplantation and graft rejection.
1. A method of treating CD5+ HLA-DR+ B or T cell related diseases in a subject in need thereof, comprising the step of administering to said subject at least one CD5 antibody and at least one HLA-DR antibody,
wherein said at least one CD5 antibody comprises:
(i) a variable light chain comprising the CDR1 (L1) of sequence SEQ ID NO: 3, the CDR2 L2 of sequence CDR3 L3 of sequence SEQ ID NO: 5 and,
(ii) a variable heavy chain comprising the CDR1 (H1) of sequence SEQ ID NO: 6, the CDR2 (H2) of sequence SEQ ID NO: 7, and the CDR3 (H3) of sequence SEQ ID NO: 8, and
wherein said at least one HLA-DR antibody comprises:
(i) a variable light chain comprising the CDR1 (L1) of sequence SEQ ID NO: 11, a CDR2 (L2) of sequence SEQ ID NO: 12, and a CDR3 (L3) of sequence SEQ ID NO: 13 and,
(ii) a variable heavy chain comprising the CDR1 (H1) of sequence SEQ ID NO: 14, a CDR2 (H2) of sequence SEQ ID NO: 15, and a CDR3 (H3) of sequence SEQ ID NO: 16.
2. The method of claim 1 , wherein the at least one CD5 antibody and the at least one HLA-DR antibody are constituents of a bispecific antibody.
3. The method of claim 1 , wherein the at least one CD5 antibody comprises a variable heavy chain of SEQ ID NO: 2.
4. The method of claim 1 , wherein the at least one HLA-DR antibody comprises a variable heavy chain of SEQ ID NO: 10.
5. The method of claim 1 , wherein the CD5+ HLA-DR+ B or T cell related disease is selected from the group consisting of B or T cell malignancies, B or T cell autoimmune diseases, transplantation diseases and graft rejections.
6. The method of claim 1 , wherein said at least one CD5 antibody and at least one HLA-DR antibody are administered in combination with at least one other compound for the treatment of at least one CD5+ HLA-DR+ B or T cell related disease selected from the group consisting of B or T cell malignancies, autoimmune diseases, transplantation diseases and graft rejections.
7. The method of claim 1 , wherein the at least one CD5 antibody comprises a variable light chain of SEQ ID NO: 1 and a variable heavy chain of SEQ ID NO: 2.
8. The method of claim 1 , wherein the at least one HLA-DR antibody comprises a variable light chain of SEQ ID NO: 9 and a variable heavy chain of SEQ ID NO: 10.
9. The method of claim 1 , wherein the at least one CD5 antibody comprises a variable light chain of SEQ ID NO: 1.
10. The method of claim 1 , wherein the at least one HLA-DR antibody comprises a variable light chain of SEQ ID NO: 9.