Method for easing human childbirth using a lubricant composition
The present invention relates to a method of easing childbirth using a composition having a lubricant effect for use in particular during human vaginal delivery. The methods comprise applying a bioadhesive composition comprising (a) a polyacrylic acid, (b) a water-soluble thickener and (c) a humectant and (d) optionally water.
1. A method for reducing the frictional force between an item to be delivered and the birth canal of the mother in human vaginal child birthing, comprising applying a composition having a lubricant effect to the birth canal of the mother, the composition comprising
(a) 0.4 to 0.7% by weight cross-linked polyacrylic acid,
(b) 1 to 6% by weight hydroxyethyl cellulose,
(c) 15 to 25% by weight propylene glycol, and
(d) sodium hydroxide, water, sodium chloride, or a combination thereof, and
wherein said composition is free of alginic acid, alginates, and silver ions.
2. The method of claim 1 , wherein
the composition is applied one or more times before or/and after the start of regular labor contractions.
3. The method of claim 1 , wherein
the composition is applied in the birth canal, where appropriate including the mouth of the womb or/and intraamniotically.
4. The method of claim 1 wherein the composition is a lubricant for facilitating removal of the placenta.
5. A method for easing human childbirth in a mother comprising applying a composition having a lubricant effect to the birth canal of the mother, said composition comprising
(a) 0.4 to 0.7% by weight cross-linked polyacrylic acid,
(b) 1 to 6% by weight hydroxyethyl cellulose,
(c) 15 to 25% by weight propylene glycol, and
(d) sodium hydroxide, water, sodium chloride, or a combination thereof, and
wherein said composition is free of alginic acid, alginates, and silver ions.
6. The method of claim 5 , wherein said composition to be applied has a pH in the range of 4-7.
7. The method of claim 5 , wherein the composition to be applied has a viscosity of 1-40 Pa·s.
8. The method of claim 5 , wherein the composition to be applied has thixotropic or/and pseudoplastic properties.
9. The method of claim 5 , wherein the composition to be applied has a conductivity of 4-25 mS·cm −1 .
10. The method of claim 5 , wherein the composition to be applied further comprises salts in a proportion by weight of approximately 0.1-5%.
11. The method of claim 5 , wherein the composition to be applied is sterilized.
12. The method of claim 5 , wherein the composition to be applied is free of preservatives.
13. The method of claim 5 , wherein the composition to be applied is in the form of a gel, a solid dosage form, a suspension, or a foam.
14. The method of claim 5 , wherein the composition to be applied additionally comprises at least one active pharmaceutical ingredient.
15. The method of claim 6 , wherein the composition to be applied has a pH in the range of 5.5-6.
16. The method of claim 7 , wherein the composition to be applied has a viscosity of 10-18 Pa·s.
17. The method of claim 9 , wherein the composition to be applied has a conductivity of 8-12 mS·cm −1 .
18. The method of claim 5 , wherein said composition comprises 0.3 to 0.6% by weight sodium chloride.
19. The method of claim 5 , wherein said composition comprises no more than 22% by weight propylene glycol.
20. The method of claim 5 , wherein the composition is applied at least once before the start of regular labor contractions.
21. A method for easing human childbirth in a mother comprising applying a composition having a lubricant effect to the birth canal of the mother, said composition consisting of
(a) 0.4 to 0.7% by weight cross-linked polyacrylic acid,
(b) 1 to 6% by weight hydroxyethyl cellulose,
(c) 10 to 30% by weight propylene glycol,
(d) 0.3 to 0.6% by weight sodium chloride,
(e) an amount of sodium hydroxide sufficient to adjust the composition's pH to 5.0 to 6.0, and
(f) water.