System and method for conditioning a diaphragm of a patient
A method of conditioning a diaphragm of a patient is provided. The method can include the steps of implanting an electrode adjacent a target site in the diaphragm of the patient and operating the electrode to deliver a sufficient amount of electrical stimulation to the target site in the diaphragm of the patient to cause the diaphragm to contract.
1. A system for conditioning a diaphragm of a patient, the system comprising:
an electrical signal generator;
an electrode coupled to the electrical signal generator, the electrode configured to be implanted adjacent a target site of the diaphragm of the patient and configured to deliver electrical stimulation to the target site of the diaphragm of the patient emitted from the signal generator; and
a breathing sensor and a control unit, the control unit in electrical communication with the breathing sensor and the electrical signal generator, wherein the breathing sensor is configured to detect a breath or a breathing attempt made by the patient and output a breathing signal to the control unit, wherein the control unit is configured to synchronize the delivery of the electrical stimulation based on the breathing signal.
2. The system of claim 1 wherein the electrode is an intramuscular electrode.
3. The system of claim 1 further comprising another electrode, wherein each electrode is configured to be implanted adjacent a phrenic nerve motor point on each hemidiaphragm of the patient.
4. The system of claim 1 wherein the target site of the diaphragm is the phrenic nerve motor point of a hemidiaphragm of the patient.
5. The system of claim 1 wherein at least one parameter of the electrical stimulation is adjustable.
6. The system of claim 5 wherein the adjustable parameter of the electrical stimulation is selected from the group consisting of pulse frequency, pulse width, current amplitude, voltage and pulse ramp time.
7. The system of claim 1 wherein the electrical stimulation is delivered periodically.
8. A system for conditioning a diaphragm of a patient, the system comprising:
a mapping electrode coupled to a mapping device, wherein the mapping electrode is configured to electrically stimulate a location on the diaphragm to generate an evoked muscle response and the mapping device is configured to measure the magnitude of the evoked muscle response to identify a target site;
an electrical signal generator; and
an electrode coupled to the electrical signal generator, the electrode configured to be implanted adjacent the target site of the diaphragm of the patient and configured to deliver electrical stimulation to the target site of the diaphragm of the patient emitted from the signal generator.
9. The system of claim 8 , further comprising a control unit in electrical communication with the electrical signal generator, the control unit configured to modulate the delivery of the electrical stimulation to the target site to elicit diaphragm muscle fiber type conversion from fast twitch to slow twitch fibers.
10. The system of claim 8 wherein the electrode is an intramuscular electrode.
11. The system of claim 8 further comprising another electrode, wherein each electrode is configured to be implanted adjacent a phrenic nerve motor point on each hemidiaphragm of the patient.
12. The system of claim 8 wherein the target site of the diaphragm is the phrenic nerve motor point of a hemidiaphragm of the patient.
13. The system of claim 8 wherein at least one parameter of the electrical stimulation is adjustable.
14. The system of claim 13 wherein the adjustable parameter of the electrical stimulation is selected from the group consisting of pulse frequency, pulse width, current amplitude, voltage and pulse ramp time.
15. The system of claim 8 wherein the electrical stimulation is delivered periodically.