Tissue repair implant
Described herein are tissue repair implants comprising at least a first layer of peritoneal membrane. The first layer of peritoneal membrane can be located adjacent to a second layer of peritoneal membrane and can be in direct contact with the second layer of peritoneal membrane. Additional layers (e.g., a third or fourth layer) can be included. Where more than one layer is present, the layers can be affixed to one another. For example, a first layer of peritoneal membrane can be attached to the second layer of peritoneal membrane by an adhesive bond, suture, or staple. One or more of the peritoneal membranes can be non-crosslinked, partially crosslinked, or substantially fully crosslinked. Any of the layers of peritoneal membrane may be attached to a wall (e.g., an interior or exterior wall) of an abdominal tissue by an adhesive, suture, and/or staples.
1. A tissue repair implant comprising a first layer of porcine peritoneal membrane comprising a first mesothelium surface and a second layer of porcine peritoneal membrane comprising a second mesothelium surface, wherein the first and second layers of porcine peritoneal membrane are derived from a porcine sow, and wherein the first layer of peritoneal membrane and the second layer of peritoneal membrane are oriented with the first and the second mesothelium surfaces in an outward direction to generate one or more adhesion-resistant organ contacting surfaces.
2. The implant of claim 1 , wherein the first layer of peritoneal membrane is located adjacent to the second layer of peritoneal membrane.
3. The implant of claim 1 , wherein the first layer of peritoneal membrane is in direct contact with the second layer of peritoneal membrane.
4. The implant of claim 1 , wherein at least one of the layers of peritoneal membrane is non-crosslinked.
5. The implant of claim 1 , wherein at least one of the layers of peritoneal membrane is partially crosslinked.
6. The implant of claim 1 , wherein at least one of the layers of peritoneal membrane is substantially fully crosslinked.
7. The implant of claim 1 , wherein the first layer of peritoneal membrane and/or the second layer of peritoneal membrane is configured to be remodeled by in-growth of tissue.
8. The implant of claim 7 , wherein the first layer of peritoneal membrane and/or the second layer of peritoneal membrane is configured to promote in-growth of tissue.
9. The implant of claim 1 , wherein the first layer of peritoneal membrane and/or the second layer of peritoneal membrane is configured to promote fluid communication.
10. The implant of claim 1 , wherein the first layer of peritoneal membrane and/or the second layer of peritoneal membrane is configured to be attached to an interior wall of an abdominal tissue.
11. The implant of claim 1 , wherein the implant is configured to treat an abdominal hernia repair, and/or as a pelvic floor reinforcement, and/or for vaginal reconstruction, and/or as a uterine wound cover, and/or for a colorectal application, and/or for a urological application, and/or for a gynecological application.
12. The implant of claim 1 , wherein the shape of the implant is pre-defined to suit the shape of an abdominal cavity.
13. The implant of claim 1 , wherein the layer of peritoneal membrane comprises interrupted sutures to retain compliance.