Self adjusting venous equalizing graft and endothelial lining therefor
View Patent ↗An improved vascular graft having increased patency is disclosed herein. The graft may comprise a central or other stenosis. In addition, in some embodiments, the graft may comprise an internal reservoir and a collapsible portion configured to self-adjust the stenosis based on blood flow pressure. The graft may comprise an endothelial lining, one or more drug eluting materials, or both to increase patency by respectively reducing clots and preventing unwanted cellular or fibrin growth. The endothelial lining may be formed from one or more endothelial cells artificially grown or harvested from a patient's vascular system.
1. A graft comprising:
a blood flow conduit, the blood flow conduit located within the graft and configured to provide a fluid pathway for blood flow between an inflow end and an outflow end of the graft;
a reservoir formed between the blood flow conduit and an outer wall of the graft;
a collapsible portion of the blood flow conduit, the collapsible portion configured to decrease the blood flow through the blood flow conduit by collapsing as a result of an increase in pressure within the reservoir;
an expandable portion of the blood flow conduit, the expandable portion configured to expand into the reservoir due to blood pressure pushing the expandable portion into the reservoir to thereby increase the pressure within the reservoir by expanding into the reservoir as a result of increased blood pressure at the outflow end of the graft such that the collapsible portion is configured to collapse in response to the expansion of the expandable portion.
2. The graft of claim 1 further comprising a drug eluting material on the interior surface of the blood flow conduit, the drug eluting material configured to release cellular growth inhibitors.
3. The graft of claim 1 , wherein the expandable portion is between the collapsible portion and the outflow end of the graft.
4. The graft of claim 1 , wherein the expandable portion tapers outward from the collapsible portion.
5. The graft of claim 1 , wherein the collapsible portion is cylindrical in shape.
6. The graft of claim 1 further comprising a tapered portion of the blood flow conduit, the tapered portion configured to direct pressure from the reservoir to the collapsible portion to collapse the collapsible portion, wherein the tapered portion tapers inward toward the collapsible portion.
7. The graft of claim 1 , further comprising an endothelial lining on an interior surface of the fluid pathway of the blood flow conduit.
8. The graft of claim 7 , wherein the drug eluting material is below the endothelial lining.
9. The graft of claim 7 , wherein the endothelial lining comprises cells harvested from a patient.
10. A method of deploying a graft comprising: storing the graft of claim 1 in a deployment shaft; advancing the deployment shaft into a vessel of a patient; and retracting the deployment shaft to deploy the graft within the vessel, wherein the graft expands upon being released from the deployment shaft.
11. The method of claim 10 , wherein the graft has an endothelial lining covering at least a portion of the interior surface.
12. The method of claim 10 further comprising depositing a drug eluting material on the interior surface of the conduit, the drug eluting material configured to release one or more cellular growth inhibitors.
13. The method of claim 12 , wherein depositing the drug eluting material on the interior surface of the conduit occurs prior to providing a endothelial lining on the graft.
14. The method of claim 11 , wherein the endothelial lining is provided by depositing endothelial cells on the internal conduit.
15. The method of claim 11 further comprising collapsing the graft and endothelial lining so that the graft may be stored within the deployment shaft.