IP Library › Granted Patent US 8,715,693
Granted Patent B2
US 8,715,693 · App. 13/423,161 · Granted May 6, 2014

Neurovirulent strain of the West Nile virus and uses thereof

Inventors: Philippe Despres (La Garenne-Colombes, FR); Vincent Deubel (Vanves, FR); Jean-Louis Guenet (Longjumeau, FR); Marie-Thérèse Drouet (Paris, FR); Mertyn Malkinson (Rehovot, IL); Caroline Banet (Beit Dagan, IL); Marie-Pascale Frenkiel (Levallois, FR); Marie-Pierre Courageot (Paris, FR); Fasséli Coulibaly (Saint-Maur, FR); Adeline Catteau (Savigny sur Orge, FR); Marie Flamand (New York, NY); Patrick Weber (Montreuil, FR); Pierre-Emmanuel Ceccaldi (Boissise-la-bertrand, FR)
Assignees: Institut Pasteur; Kimron Veterinary Institute
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,715,693
App. No.
13/423,161
Granted
May 6, 2014
Kind
B2
Abstract

Neuroinvasive and neurovirulent strain of the West Nile virus, named IS-98-ST1, nucleic acid molecules derived from its genome, proteins and peptides encoded by said nucleic acid molecules, and uses thereof.

Claims (21)

1. A recombinant protein comprising at least one amino acid sequence selected from:

the amino acid sequence extending from the amino acid at position 291 to the amino acid at position 791 of the sequence SEQ ID NO. 2;

the amino acid sequence extending from the amino acid sequence extending from the amino acid at position 792 to the amino acid at position 1144 of the sequence SEQ ID NO. 2;

the amino acid sequence extending from the amino acid at position 1145 to the amino acid at position 1374 of the sequence SEQ ID NO. 2;

the amino acid sequence extending from the amino acid at position 1375 to the amino acid at position 1505 of the sequence SEQ ID NO. 2;

the amino acid sequence extending from the amino acid at position 1506 to the amino acid at position 2124 of the sequence SEQ ID NO. 2; and

the amino acid sequence extending from the amino acid at position 2529 to the amino acid at position 3430 of the sequence SEQ ID NO. 2.

2. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid at position 291 to the amino acid at position 791 of the sequence SEQ ID NO. 2.

3. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid sequence extending from the amino acid at position 792 to the amino acid at position 1144 of the sequence SEQ ID NO. 2.

4. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid at position 1145 to the amino acid at position 1374 of the sequence SEQ ID NO. 2.

5. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid at position 1375 to the amino acid at position 1505 of the sequence SEQ ID NO. 2.

6. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid at position 1506 to the amino acid at position 2124 of the sequence SEQ ID NO. 2.

7. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence extending from the amino acid at position 2529 to the amino acid at position 3430 of the sequence SEQ ID NO. 2.

8. The recombinant protein according to claim 1 , wherein the recombinant protein comprises the amino acid sequence SEQ ID NO. 2.

9. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid at position 291 to the amino acid at position 791 of the sequence SEQ ID NO. 2.

10. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid sequence extending from the amino acid at position 792 to the amino acid at position 1144 of the sequence SEQ ID NO. 2.

11. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid at position 1145 to the amino acid at position 1374 of the sequence SEQ ID NO. 2.

12. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid at position 1375 to the amino acid at position 1505 of the sequence SEQ ID NO. 2.

13. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid at position 1506 to the amino acid at position 2124 of the sequence SEQ ID NO. 2.

14. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence extending from the amino acid at position 2529 to the amino acid at position 3430 of the sequence SEQ ID NO. 2.

15. The recombinant protein according to claim 1 , wherein the recombinant protein consists of the amino acid sequence SEQ ID NO. 2.

Priority Claims (2)
FR 01 04599 · Apr 4, 2001 · national
FR 01 11525 · Sep 6, 2001 · national
Continuity (4)
Continuation 12112366 · Apr 30, 2008
Division 10956085 · Oct 4, 2004
Continuation 10474186
Related Publication 20120266261A1 · Oct 18, 2012