Method to make porous materials and their applications
View Patent ↗The present invention relates a method to make porous materials which are useful in pharmaceutical, medicine, industry, and agriculture. The most advantage of the porous materials is to provide extremely large surface area for further modification and to incorporate a bioactive reagent in a mild condition to make the porous materials bioactive, biocompatible and biodegradable.
1. A method of making a porous material comprising: dissolving a material in a solvent one, precipitating the material with a solvent two, washing and centrifuging the precipitated material with a solvent three, modeling the precipitated material in the shape of a macrosphere, a bead, a column, a film, a square, a cube, a coil, or a sheet, freezing the precipitated material at about −80° C. to form the porous material, and thawing the porous material, wherein the porous material is useful in pharmaceutical, medicine, industry, and agriculture applications and wherein the material is selected from the group consisting of an albumin or a chitosan.
2. The method of claim 1 further comprising conjugating the porous material with a substrate.
3. The method of claim 2 , wherein the substrate is selected from the group consisting of a chelator, a drug, a prodrug, a peptide, a protein, an enzyme, an enzyme inhibitor, a cytokine, a chemokine, a hormone, hormone inhibitor, a growth factor, a growth factor inhibitor, a receptor, a receptor inhibitor, a ligand, a lipid, a nucleotide, a electronic sensor, a photo sensor, a magnetic sensor, a pH sensor, a reactive molecule, and a pharmaceutical reagent.
4. The method of claim 3 , wherein the substrate is conjugated to the porous material with or without a linker.
5. The method of claim 4 , wherein the linker is selected from the group consisting of formaldehyde, glyceraldehyde, glutaraldehyde, dextran dialdehyde, and ethylene glycol.
6. The method of claim 2 further comprising binding the substrate to a radionuclide or a metal ion to form a therapeutic reagent.
7. The method of claim 6 , wherein the radionuclide is selected from the groups consisting of an alpha-emitting radionuclide, a beta-emitting radionuclide and a gamma-emitting radionuclide.
8. The method of claim 6 , wherein the radionuclide is selected from the group consisting of yttrium-90, holmium (166Ho), lutetium (177Lu), rhenium, (Re-186, Re-188), strontium (89Sr, 90Sr), samarium (153Sm), actinium (225Ac), bismuth (212Bi, 213Bi), lead (212Pb), radium, dysprosium (165Dy), gold (198 Au), copper (67Cu), scandium (47Sc), gallium (67Ga), rhodium (105Rh), praseodymium (142Pr), neodymium (147Nd), promethium (151Pm), gadolinium (159Gd), thorium (161Th), europium (152Eu), erbium (169Er, 171Er), thallium (201Tl), palladium (Pd103), astatine (211At), iodine (123I, 125I, and 131I), and phosphorus (32 P).
9. The method of claim 1 , wherein the solvent one is selected from the soup consisting of an organic acid, an inorganic acid, an organic base, an inorganic base, and water.
10. The method of claim 1 , wherein the solvent two from the group consisting of an organic base, an inorganic base, an organic acid, an inorganic acid, and water, and selection of solvent two is depend on what type of solvent one is used.
11. The method of claim 1 , wherein the solvent three is water.