Transcutaneous analyte sensor
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
1. An analyte monitoring system, the system comprising:
an analyte sensor;
a processor coupled to the sensor and configured to provide sensor data indicative of a concentration of glucose measured by the analyte sensor in a subcutaneous tissue of a host; and
a user interface configured to provide real-time glucose information based on calibrated sensor data to a user, wherein the system is configured to calibrate the analyte sensor using reference data from a reference analyte monitor, wherein the calibration is allowed when an absolute rate of change of a calculated glucose concentration is less than about 4 mg/dL/min, and wherein the calibration is suspended when the absolute rate of change of the calculated glucose concentration is greater than about 4 mg/dL/min.
2. The system of claim 1 , wherein the system is configured to prospectively calibrate the analyte sensor.
3. The system of claim 1 , wherein the system is configured to calculate the rate of change of the glucose concentration from calibrated sensor data.
4. The system of claim 1 , wherein the analyte sensor is a subcutaneous glucose sensor configured to continuously measure a glucose concentration in a subcutaneous tissue of a host.
5. The system of claim 1 , wherein the analyte sensor is a transcutaneous glucose sensor configured to continuously measure a glucose concentration in a subcutaneous tissue of a host.
6. The system of claim 1 , wherein the sensor data is indicative of the continuous concentration of glucose in the subcutaneous tissue of the host over a period of time.
7. The system of claim 1 , wherein the reference analyte monitor is a self-monitoring blood glucose meter.
8. The system of claim 1 , wherein the reference data is indicative of a blood glucose concentration withdrawn from a finger stick and analyzed by the reference analyte monitor.
9. The system of claim 1 , wherein the system is configured to calibrate the analyte sensor multiple times over a period of time.
10. A method of calibrating an analyte monitoring system, the method comprising:
receiving sensor data from an analyte sensor, wherein the sensor data is indicative of a glucose concentration measured in a subcutaneous tissue of a host;
receiving reference data from a reference analyte monitor;
calibrating, using an electronic system, the analyte sensor using the reference data, wherein calibrating comprises allowing calibration when an absolute rate of change of a calculated glucose concentration is less than about 4 mg/dL/min and suspending calibration when the absolute rate of change of the calculated concentration is greater than about 4 mg/dL/min; and
providing real-time glucose information based on calibrated sensor data.
11. The method of claim 10 , wherein the calibrating is performed prospectively.
12. The method of claim 10 , further comprising calculating the rate of change of the glucose concentration from calibrated sensor data.
13. The method of claim 10 , wherein the analyte sensor is a subcutaneous glucose sensor configured to continuously measure a glucose concentration in a subcutaneous tissue of a host.
14. The method of claim 10 , wherein the analyte sensor is a transcutaneous glucose sensor configured to continuously measure a glucose concentration in a subcutaneous tissue of a host.
15. The method of claim 10 , wherein the sensor data is indicative of the continuous concentration of glucose in the subcutaneous tissue of the host over a period of time.
16. The method of claim 10 , wherein the reference analyte monitor is a self-monitoring blood glucose meter.
17. The method of claim 10 , wherein the reference data is indicative of a blood glucose concentration withdrawn from a finger stick and analyzed by the reference analyte monitor.
18. The method of claim 10 , further comprising performing a first calibration of the analyte sensor prior to performing the calibration of the analyte sensor using the reference data.