Cellulosic-based resistance domain for an analyte sensor
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain.
1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the macromolecular resistance domain comprises at least one hydrophilic moiety and at least one hydrophobic moiety; wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.
2. The sensor of claim 1 , wherein the hydrophobic moiety is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy.
3. The sensor of claim 2 , wherein the hydrophobic moiety is acetyl.
4. The sensor of claim 3 , wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl.
5. The sensor of claim 1 , wherein the hydrophilic moiety is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl.
6. The sensor of claim 5 , wherein the hydrophilic moiety is hydroxyl.
7. The sensor of claim 6 , wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl.
8. The sensor of claim 1 , wherein the sensor is a needle sensor configured for transcutaneous insertion into the host.
9. The sensor of claim 1 , wherein the sensor is configured for wholly implanting into the host.
10. The sensor of claim 1 , wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue.
11. The sensor of claim 1 , wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion.
12. The sensor of claim 1 , wherein the membrane system is an ionizing radiation-treated membrane system.
13. An implantable glucose sensor for measuring glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, wherein the membrane system comprises a resistance domain configured to control a flux of glucose therethrough, and wherein the resistance domain incorporates hydrophilic substituents and hydrophobic substituents to form a macromolecular structure; wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L.
14. The sensor of claim 13 , wherein the hydrophobic substituent is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy.
15. The sensor of claim 13 , wherein the hydrophobic substituent is acetyl.
16. The sensor of claim 15 , wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl.
17. The sensor of claim 13 , wherein the hydrophilic substituent is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl.
18. The sensor of claim 13 , wherein the hydrophilic moiety is hydroxyl.
19. The sensor of claim 18 , wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl.
20. The sensor of claim 13 , wherein the sensor is a needle sensor configured for transcutaneous insertion into the host.
21. The sensor of claim 13 , wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue.
22. The sensor of claim 13 , wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion.
23. The sensor of claim 13 , wherein the membrane system is an ionizing radiation-treated membrane system.