Injectable bulking compositions
According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable.
1. An injectable bulking composition comprising: (a) fibers that are configured to prevent migration of the fibers to locations in the body remote from the injection site, wherein said fibers are biostable and comprise a synthetic organic polymer selected from poly(vinyl alcohol) homopolymers and copolymers, and ethylene-vinyl acetate copolymers, and (b) a carrier in an amount effective to render the composition injectable.
2. The injectable bulking composition of claim 1 , wherein the majority of the fibers have a length that is at least 20 times longer than the greatest width of the fiber.
3. The injectable bulking composition of claim 1 , wherein the majority of the fibers have a length that is at least 50 times longer than the greatest width of the fiber.
4. The injectable bulking composition of claim 1 , further comprising a therapeutic agent in an amount effective to increase the long term tissue bulking effect of said composition, to increase fibroblast attachment, to attract cellular migration to the injection site, to promote the formation of organized soft tissue, or a combination of these effects.
5. The injectable bulking composition of claim 4 , wherein said therapeutic agent comprises cells.
6. The injectable bulking composition of claim 4 , wherein said therapeutic agent comprises cells selected from stem cells, fibroblast cells, and cardiac muscle cells.
7. The injectable bulking composition of claim 4 , wherein said therapeutic agent comprises a proinflammatory agent.
8. The injectable bulking composition of claim 4 , wherein said therapeutic agent comprises a sclerosing agent.
9. The injectable bulking composition of claim 4 , wherein said therapeutic agent is selected from growth factors and hormones.
10. The injectable bulking composition of claim 1 , wherein said composition contains from 50 to 80 wt % fibers.
11. The injectable bulking composition of claim 1 , wherein a majority of said fibers have a maximum length that is less than 1000 microns.
12. The injectable bulking composition of claim 1 , wherein said fibers have a length that is sufficiently large to prevent said migration.
13. The injectable bulking composition of claim 1 , wherein said fibers have surface features that stimulate host tissue response so as to prevent said migration.
14. A method of treating urinary incontinence, comprising administering an effective amount of the composition of claim 1 to a subject's urethra.
15. A method of cosmetic bulking, comprising administering a cosmetically effective amount of the composition of claim 1 to a subject.
16. The injectable bulking composition of claim 1 , further comprising an imaging contrast agent.
17. The injectable bulking composition of claim 16 , wherein the imaging contrast agent is a magnetic resonance imaging (MRI) contrast agent.
18. The injectable bulking composition of claim 16 , wherein the imaging contrast agent is an ultrasonic imaging contrast agent.
19. The injectable bulking composition of claim 16 , wherein the imaging contrast agent is an x-ray fluoroscopy contrast agent.
20. The injectable bulking composition of claim 1 , wherein the fibers range from 1 to 1000 microns in length.