Anti-hypertensive functional food products
The present invention provides novel protein hydrolysates with anti-hypertensive properties, as well as food products and food supplements comprising these.
1. A food product or food supplement, comprising a Bacillius licheniformi endoproteinase hydrolysate of a lysozyme, wherein at least 30% of the hydrolysate are peptides of the lysozyme that have a molecular weight of less than 0.5 kD.
2. An enzymatic protein hydrolysate, wherein said hydrolysate is obtained by Bacillius licheniformi endoproteinase hydrolysis of a lysozyme and wherein at least 30% of the hydrolysate are peptides of the lysozyme that have a molecular weight of less than 0.5 kD.
3. A method for making a protein hydrolysate with anti-hypertensive activity, comprising the steps of:
(a) providing a liquid solution comprising a lysozyme;
(b) adjusting the pH of said solution to a pH suitable for Bacillius licheniformi endoproteinase; and
(c) adding Bacillius licheniformi endoproteinase to said solution and incubating the solution for a suitable period at a suitable temperature to obtain a hydrolysate of the lysozyme wherein at least 30% of the hydrolysate are peptides of the lysozyme that have a molecular weight of less than 0.5 kD.
4. The method according to claim 3 , further comprising a step (e) of filtering said solution through a membrane filter and obtaining a permeate which is enriched for active target peptides.
5. An anti-hypertensive protein hydrolysate, said hydrolysate obtained by the method according to claim 3 .
6. The food product or food supplement according to claim 1 , wherein said product or supplement is in the form of a liquid, solid or semi-solid.
7. A food product or food supplement, said food product or food supplement comprising the hydrolysate according to claim 5 .
8. The enzymatic protein hydrolysate according to claim 2 , wherein the proportion of di- and/or tri peptides in the hydrolysate is at least 50%.
9. The enzymatic protein hydrolysate according to claim 2 , wherein at least 50% of the hydrolysate are peptides that have a molecular weight of less than 0.5 kD.
10. The food product or food supplement according to claim 1 , wherein the proportion of di- and/or tri peptides of lysozyme in the hydrolysate is at least 50%.
11. The food product or food supplement according to claim 1 , wherein at least 50% of the hydrolysate are peptides that have a molecular weight of less than 0.5 kD.
12. A method of reducing blood pressure or reducing the risk of developing high blood pressure comprising administering a food product or food supplement comprising a Bacillius licheniformi endoproteinase hydrolysate of a lysozyme, wherein at least 30% of the hydrolysate are peptides of the lysozyme that have a molecular weight of less than 0.5 kD.
13. A food product or food supplement comprising the enzymatic protein hydrolysate according to claim 2 .