Circumferential aerosol device
View Patent ↗The present application discloses devices and methods for delivering a therapeutic compound to the olfactory epithelium of an animal or human. The device having one or more channels for imparting a circumferential and axial velocity to the discharged fluid, and an outlet that discharges an aerosol spray having a circumferential and axial velocity as it enters the nasal cavity of a user. The device is designed to displace the air in the upper nasal cavity in order to specifically deposit a therapeutic agent on the olfactory epithelium while minimizing pressure and discomfort experienced by the user.
1. A pressurized olfactory drug delivery device comprising:
(a) a reservoir containing a therapeutic compound;
(b) a container containing a pressurized propellant fluid;
(c) a delivery device defining a longitudinal axis and having:
(i) an exit opening at a proximal end of the delivery device,
(ii) a first channel having a distal end and a proximal end, the first channel extending from the distal end of the first channel at the reservoir to the proximal end of the first channel at the exit opening, and
(iii) a second channel having a distal end and a proximal end, the second channel extending from the distal end of the second channel at the container to the proximal end of the second channel at the exit opening, the first channel and the second channel in fluid communication with the exit opening; and
(d) a metering device configured for selectively discharging a circumferential helical flow of the pressurized propellant fluid through the second channel;
wherein the second channel receives at the distal end of the second channel and delivers at the proximal end of the second channel the circumferential helical flow, and the circumferential helical flow entrains a portion of the therapeutic compound through the first channel at the exit opening.
2. The pressurized olfactory drug delivery device of claim 1 , further comprising a plurality of outlets at the distal end of the second channel for discharging the pressurized propellant fluid.