Cannabinoid receptor binding agents, compositions, and methods

1. A composition, comprising:

a. cannabidiol present at about 1% to about 55% by weight of the composition, wherein the cannabidiol is selected from the group consisting of cannabidiol-C5, cannabidiol momomethyl ether, cannabidiol-C4, cannabidivarin, cannabidiorcol, cannabidiolic acid, and cannabidivarinic acid;

b. a polymeric nano article containing the cannabidiol wherein the particle at its largest dimension is smaller than 400 nanometers and greater than 0 nanometers, wherein the polymeric nanoparticle comprises a biodegradable polymer, wherein the polymeric nanoparticle is attached to a functional moiety, wherein the polymeric nanoparticle is present at 75% or less and greater than 1% by weight of the composition to alter a pharmacokinetic property of the cannabidiol, and wherein the biodegradable polymer is selected from the group consisting of polylactides, polyglycolides, poly(lactide-co-glycolide)s, polylactic acids, polyglycolic acids, poly(lactic acid-co-glycolic acid)s, copolymers of polylactides and poly(lactide-co-glycolide)s, poly(amino acids), polyacrylates polyketals, collagen, chitin, chitosan, dextran alginate, gelatin, albumin, ovalbumin, elastin, laminin, fibronectin, polymerized starches, chondroitin sulfate, polysucrose, hyaluronic acid, and heparin;

c. a vesicle for carrying the cannabidiol and the particle; and

d. a substrate for delivering the cannabidiol and the particle in the vesicle, wherein the substrate is selected from the group consisting of a patch and a non-solid composition that is solidified when exposed to a suitable agent selected from the group consisting of light, heat, and a chemical activating agent.

2. The composition of claim 1 , wherein the composition comprises cannabidiol present at approximately 15% to about 40% by weight of the total composition.

3. The composition of claim 1 , wherein the cannabidiol is present at about 30% to about 40% by weight of the composition.

4. The composition of claim 1 , wherein the cannabidiol is present at about 1% to about 10% by weight of the composition.

5. The composition of claim 1 , wherein the polymeric nanoparticle comprises a nanocrystalline cellulose present at about 5% to about 40% by weight of the composition.

6. A composition, comprising:

a. cannabidiol present at about 1% to about 55% by weight of the composition, wherein the cannabidiol is selected from the group consisting of cannabidiol-C5, cannabidiol momomethyl ether, cannbidiol-C4, cannabidivarin, cannabidiorcol, cannabidiolic acid, and cannabidivarinic acid; and

b. a polymeric nanoparticle containing the cannabidiol, wherein the polymeric nanoparticles are present at about 75% or less and greater than 1% by weight of the composition, wherein the particles at their largest dimensions are smaller than 400 nanometers and greater than zero nanometers, and wherein the polymeric nanoparticles comprise a biodegradable polymer selected from the group consisting of polylactides, polyglycolides, poly(lactide-co-glycolide)s, polylactic acids, polyglycolic acids, poly(lactic acid-co-glycolic acid)s, copolymers of polylactides, and poly(lactide-co-glycolide)s, poly(amino acids) polyacrylates, polyketals, collagen, chitin, chitosan dextran, alginate gelatin, albumin, ovalbumin, elastin, laminin, fibronectin, polymerized starches, chondroitin sulfate, polysucrose, hyaluronic acid, and heparin; and

c. a substrate for delivering the cannabidiol and the particle, wherein the substrate is selected from the group consisting of a patch and a non-solid composition that is solidified when exposed to a suitable agent selected from the group consisting of light, heat, and a chemical activating agent.

7. The composition of claim 6 , wherein the composition comprises about 15% to about 40% by weight of the cannabidiol.

8. The composition of claim 6 , wherein the cannabidiol s present at about 30% to about 40% by weight of the composition.

9. The composition of claim 6 , wherein the cannabidiol is present at about 10% by weight of the composition or less.

10. The composition of claim 6 , wherein the polymeric nanoparticles are nanocrystalline cellulose recent at about 5 to about 40% by weight of the composition.

11. The composition of claim 6 , further comprising a patch to deliver the composition to an affected area.

12. The composition of claim 6 , further comprising a non-solid substrate that solidifies after administration when exposed to a suitable agent selected from the group consisting of a light, a temperature, and a chemical activating agent after administration.

13. The composition of claim 6 , further comprising a vesicle to encapsulate the cannabidiol and polymeric nanoparticles to modify a property of the composition, the vesicle selected from the group consisting of liposomes, ethosomes, niosomes, and transferosomes.

14. The composition of claim 6 , wherein the polymeric nanoparticle is attached to a moiety, wherein the moiety, comprises:

a. a sulfonate attached to the polymeric nanoparticle,

b. a spacer attached to the sulfonate, and

c. a functional group attached to the sulfonate via the spacer.

15. The composition of claim 14 , wherein the polymeric nanoparticie further comprises a coating selected from the group consisting of albumin and silicone.

16. The composition of claim 1 , further comprising a second biodegradable polymer selected from the group consisting of poloxamines, polyalkylene oxides, polyethylene oxides, and poly(propyl oxides).

17. The composition of claim 6 , further comprising a second biodegradable polymer selected from the group consisting of poloxamines, polyalkylene oxides, polyethylene oxides, and poly(propylene oxides).