Particulate cartilage system
The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
1. A composition comprising minced juvenile cartilage particles and a retainer.
2. The composition of claim 1 , further comprising a matrix.
3. The composition of claim 2 , wherein the matrix comprises a biocompatible chondro-inductive matrix.
4. The composition of claim 2 , wherein the matrix comprises a biocompatible chondro-conductive matrix.
5. The composition of claim 1 , wherein the juvenile cartilage particles comprise articular cartilage.
6. The composition of claim 1 , wherein the juvenile cartilage particles include one dimension of 1 to 3 mm.
7. The composition of claim 1 , wherein the juvenile cartilage particles are 1 to 27 mm 3 .
8. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor less than fifteen years of age at the time of donation.
9. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor less than two years of age at the time of donation.
10. The composition of claim 1 , wherein the juvenile cartilage particles are from a human donor that is prepubescent at the time of donation.
11. The composition of claim 1 , wherein the juvenile cartilage particles have a surface-to-volume ratio greater than 1.
12. The composition of claim 1 , wherein the juvenile cartilage particles are from a donor non-autologous to a recipient.
13. The composition of claim 2 , wherein the juvenile cartilage particles are distributed within about 60% or less of the matrix.
14. The composition of claim 2 wherein the juvenile cartilage particles are distributed within about 20% or less of the matrix.
15. The composition of claim 1 , wherein the retainer is selected from the group consisting of a flap, a plug, a disc, a sheet and a patch.
16. The composition of claim 1 , wherein the retainer comprises a periosteal flap.
17. The composition of claim 1 , wherein the retainer comprises a synthetic membrane.
18. The composition of claim 1 , wherein the retainer comprises a sutureless attachment.
19. The composition of claim 2 , wherein the matrix comprises fibrin.
20. The composition of claim 2 , wherein the matrix comprises polyethylene glycol.
21. The composition of claim 2 , wherein the matrix is selected from the group consisting of plasma-based adhesives or sealants, protein-based adhesives or sealants, natural adhesives or sealants, and any combination thereof.
22. The composition of claim 2 , wherein the matrix comprises an osteo-conductive matrix.
23. The composition of claim 2 , wherein the matrix comprises a media suitable for tissue or cell culture.