Composition and methods for modulating cell proliferation and cell death
Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
1. A method of inducing tumor cell apoptosis, wherein the tumor is a non-small cell lung carcinoma (NSCLC), comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO: 1, wherein the NSCLC is p53 negative, and wherein the nucleic acid is encapsulated in a liposome.
2. The method of claim 1 wherein the composition is administered in combination with a first anticancer agent, radiotherapy, or combinations thereof.
3. The method of claim 2 wherein the composition is administered in combination with a second anticancer agent.