Pyrrolotriazine compounds

1. A compound represented by formula (I)

wherein ring1 represents benzene which is optionally substituted with 1-5 substituent(s) selected from the group consisting of halogen, a C1-4 alkyl, CF 3 , nitrile, CONH 2 , and OR 5-103 ;

R 1 represents halogen or a C1-4 alkoxy;

L represents —O— or —S—;

R 2 represents (1) a C1-4 alkyl substituted with OR 5-103 , (2) C2-4 alkenyl, or (3) ring2 optionally substituted with one or more —K—R 3 ;

ring2 represents (1) a C4-7 carbocyclic ring or (2) a 4-7 membered heterocyclic ring, any atom of which is optionally substituted with one or more oxo group;

K represents bond, a C1-4 alkylene, —C(O)CH 2 —, —C(O)CH 2 CH 2 —, —C(O)O—, —CH 2 C(O)—, —CH 2 C(O)O—, —C(O)—, —CH 2 O—, —CH 2 CH 2 O—, —O—, —OCH 2 —, —OCH 2 C(O)— or —SO 2 —, wherein the left bond binds to ring2;

R 3 represents (1) hydrogen, (2) NR 3-101 R 3-102 , (3) a C1-4 alkyl optionally substituted with NR 3-101 R 3-102 , (4) a C2-4 alkenyl optionally substituted with NR 3-101 R 3-102 , (5) CF 3 , (6) nitrile, (7) halogen, or (8) a cyclic ring optionally substituted with 1-5 substituent(s) selected from the group consisting of halogen, a C1-4 alkyl, a C1-4 alkoxy, CF 3 , nitrile and oxo, wherein the cyclic ring is selected from the group consisting of morpholine, pyrrolidine, benzene, piperazine, tetrahydropyran, piperidine, tetrahydrofuran, oxazole, thiazole, pyrazole and oxadiazole;

R 4 represents (1) halogen, (2) CONR 4-101 R 4-102 , (3) CO 2 R 4-103 , (4) ring3, (5) a C1-4 alkyl which is substituted with 1-5 substituent(s) selected from ring4, nitrile, NR 4-101 R 4-102 , CONR 4-101 R 4-102 , COR 4-103 , COR 4-103 , OR 4-103 , SOR 4-103 , and SO 2 R 4-103 , or (6) a C2-4 alkenyl which is substituted with 1-5 substituent(s) selected from ring4, nitrile, NR 4-101 R 4-102 , CONR 4-101 R 4-102 , CO 2 R 4-103 , COR 4-103 , OR 4-103 , SOR 4-103 and SO 2 R 4-103 ;

R 3-101 and R 3-102 each independently represent (1) hydrogen, (2) a C1-4 alkyl, (3) COR 3-103 , (4) CONR 3-103 R 3-104 or (5) SO 2 R 3-103 , wherein R 3-103 and R 3-104 each independently represent hydrogen or a C1-4 alkyl;

R 4-101 , R 4-102 and R 4-103 each independently represent (1) hydrogen, (2) COR 5-103 , (3) NR 5-101 R 5-102 , (4) ring5, or (6) a C1-4 alkyl optionally substituted with CO 2 R 5-103 , OR 5-103 , or NR 5-101 R 5-102 ;

R 5-101 , R 5-102 and R 5-103 each independently represent hydrogen or a C1-4 alkyl;

ring3, ring4 and ring5 each independently represent a 4-7 membered heterocyclic ring optionally substituted with 1-5 substituent(s) selected from the group consisting of halogen, oxo, a C1-4 alkyl, a C1-4 alkoxy, CF 3 , CONR 5-101 R 5-102 , CO 2 R 5-103 , SOR 5-103 , SO 2 R 5-103 and nitrile;

n represents 0 or 1;

a salt thereof or a solvate thereof.

2. The compound according to claim 1 , wherein the ring2 is selected from the group consisting of cyclopentane, cyclohexane, cycloheptane, benzene, azetidine, pyrrolidine, tetrahydropyridine, piperidine, perhydroazepine, morpholine, piperazine, pyran, thiopyran, pyridine, pyrazole, isoindoline and perhydroisoquinoline.

3. The compound according to claim 1 , wherein halogen in R 4 is chlorine;

ring3 in R 4 is selected from the group consisting of pyrrolidine, piperidine, morpholine, tetrahydrothiopyran and pyridine; or

ring4 in R 4 is selected from the group consisting of pyrrolidine, piperidine, morpholine, imidazole, tetrazole and pyridine.

4. The compound according to claim 3 , wherein R 4 is (1) chlorine, (2) piperidine, (3) tetrahydrothiopyran, (4) pyrrolidine, (5) morpholine, (6) a C1-4 alkyl which is substituted with substituent(s) selected from the group consisting of NR 4-101 R 4-102 , CO 2 R 4-103 , OR 4-103 , pyrrolidine, morpholine and pyridine, or (7) a C2-4 alkenyl which is substituted with substituent(s) selected from the group consisting of NR 4-101 R 4-102 , CO 2 R 4-103 , OR 4-103 , pyrrolidine, morpholine and pyridine, wherein all the symbols have the same meanings as described in claim 1 .

5. The compound according to claim 1 , which is a compound represented by formula (I-1)

wherein ring1-1 represents benzene which may be optionally substituted with 1-5 substituent(s) selected from the group consisting of halogen, a C1-4 alkyl, CF 3 , and nitrile;

ring2-1 represents cyclopentane, cycloheptane, benzene, azetidine, tetrahydropyridine, or piperidine optionally substituted with K—R 3 ,

R 4-1 represents (1) chlorine, (2) piperidine, (3) tetrahydrothiopyran, (4) pyrrolidine, (5) morpholine (6) a C1-4 alkyl which is substituted with 1-5 substituent(s) selected from the group consisting of NR 4-101 R 4-102 , CO 2 R 4-103 , OR 4-103 , pyrrolidine, morpholine and pyridine, or (7) a C2-4 alkenyl which is substituted with 1-5 substituent(s) selected from the group consisting of NR 4-101 R 4-102 , CO 2 R 4-103 , OR 4-103 , pyrrolidine, morpholine and pyridine;

the other symbols have the same meanings as claim 1 .

6. The compound according to claim 1 , which is

(1) 5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-(3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(2) 6-(3-(dimethylamino)propyl)-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(3) 7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(4) 5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-7-(3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(5) 5-[4-(3-chlorophenoxy)phenyl]-7-(3-methoxyphenyl)-6-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(6) 5-[4-(3-chlorophenoxy)phenyl]-7-cyclopentyl-6-(4-morpholinylmethyl)pyrrolo[2,1-7f][1,2,4]triazin-4-amine,

(7) 1-(4-(4-amino-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)-2-(diethylamino)ethanone,

(8) 1-(4-(4-amino-5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)-2-(diethylamino)ethanone,

(9) 7-cyclopentyl-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-6-(2-(pyridin-3-yl)ethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(10) 7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)-6-[2-(3-pyridinyl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(11) 5-[4-(3,4-dichlorophenoxy)phenyl]-7-(3-methoxyphenyl)-6-[2-(3-pyridinyl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(12) 7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(13) 7-cyclopentyl-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(14) 5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-cyclopentyl-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(15) 3-(4-(4-amino-7-cyclopentyl-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-methoxyphenoxy)benzonitrile,

(16) 5-[4-(3,4-dichlorophenoxy)-3-methoxy-phenyl]-7-(1-methylsulfonyl-4-piperidyl)-6-(4-piperidyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(17) 5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-(1-(methylsulfonyl)piperidin-4-yl)-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(18) (3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-6-(4-pyridinyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)(4-methyl-1-piperazinyl)methanone,

(19) 7-cycloheptyl-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(20) 5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-cycloheptyl-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(21) 5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(22) 5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(23) N-(4-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-N-methylmethanesulfonamide,

(24) 5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(4-methoxyphenyl)-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(25) N-(4-{4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-N-methylmethanesulfonamide,

(26) 3-{4-[4-amino-7-(4-methoxyphenyl)-6-(4-piperidinyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-methoxyphenoxy}benzonitrile,

(27) 6-chloro-5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-(1-(methylsulfonyl)piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(28) 1-(3-(4-amino-6-chloro-5-(4-(3-chlorophenoxy)-3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one,

(29) 1-(3-(4-amino-6-chloro-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one,

(30) 5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-cyclopentyl-6-(pyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(31) 5-[4-(3-chlorophenoxy)phenyl]-7-cyclopentyl-6-(2-ethoxyethyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(32) 3-{4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(33) {4-amino-7-cyclopentyl-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}acetic acid,

(34) 2-{4-amino-7-cyclopentyl-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}ethanol,

(35) methyl 4-amino-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate,

(36) 4-amino-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid,

(37) ethyl 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoate,

(38) 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid,

(39) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(1-propen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(40) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylonitrile,

(41) methyl ({[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]carbonyl}amino)acetate,

(42) 6-fluoro-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(43) ethyl (2E)-3-[7-(1-acryloyl-3-methoxy-3-azetidinyl)-4-amino-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate,

(44) 3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-2-methylacrylic acid,

(45) (2E)-3-{4-amino-7-cyclopentyl-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}acrylic acid,

(46) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylamide,

(47) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-2-propen-1-ol,

(48) 6-(2-aminoethyl)-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(49) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylohydrazide,

(50) 3-{4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanamide,

(51) (2E)-1-(3-[4-amino-6-chloro-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-1-piperidinyl)-4-(dimethylamino)-2-buten-1-one,

(52) 1-(3-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-1-pyrrolidinyl)-2-propen-1-one,

(53) 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(54) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-cyclopentylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(55) 4-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}butanoic acid,

(56) 4-{4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}butanoic acid,

(57) 3-(4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-{4-[(methylsulfonyl)amino]phenyl}pyrrolo[2,1-f][1,2,4]triazin-6-yl)propanoic acid,

(58) (2E)-3-[4-amino-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(59) 1-(3-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-3-methoxy-1-azetidinyl)-2-propen-1-one,

(60) 5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)-6-[2-(1H-tetrazol-5-yl)ethyl]pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(61) 3-{4-amino-5-[4-(3-chlorophenoxy)phenyl]-7-cyclopentylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(62) 3-{4-amino-7-cyclopentyl-5-[4-(3,4-dichlorophenoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(63) 3-[4-amino-7-cyclopentyl-5-{4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(64) 3-(4-amino-7-cyclopentyl-5-{4-[3-(2-propanyl)phenoxy]phenyl}pyrrolo[2,1-f][1,2,4]triazin-6-yl)propanoic acid,

(65) 3-{7-(1-acryloyl-1,2,5,6-tetrahydro-3-pyridinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(66) 3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propanoic acid,

(67) 3-[4-amino-7-cyclopentyl-5-(3-hydroxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propanoic acid,

(68) 1-(3-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-hydroxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-1-piperidinyl)-2-propen-1-one,

(69) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(70) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(4-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(71) 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(72) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-phenylpyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(73) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(2-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(74) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(3-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(75) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(4-fluorophenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(76) 3-{4-amino-7-cyclopentyl-5-[4-(3,5-difluorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(77) 3-{4-amino-7-cyclopentyl-5-[4-(3,5-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(78) 3-{4-amino-7-(3-carbamoylphenyl)-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(79) 3-{4-amino-7-cyclopentyl-5-[4-(3,5-difluorophenoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(80) 3-{4-amino-7-cyclopentyl-5-[4-(3,5-dichlorophenoxy)phenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(81) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(82) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-(2-hydroxy-2-propanyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(83) ({[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]carbonyl}amino)acetic acid,

(84) 3-(4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-{4-[methyl(methylsulfonyl)amino]phenyl}pyrrolo[2,1-f][1,2,4]triazin-6-yl)propanoic acid,

(85) 3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-[4-(methylsulfonyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(86) 1-[5-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,6-dihydro-1(2H)-pyridinyl]-2-propen-1-one,

(87) 3-[4-amino-7-{4-[methyl(methylsulfonyl)amino]phenyl}-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propanoic acid,

(88) (2E)-3-[4-amino-7-(2-hydroxy-2-propanyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(89) 3-(4-amino-7-cyclopentyl-5-{3-methoxy-4-[3-(2-propanyl)phenoxy]phenyl}pyrrolo[2,1-f][1,2,4]triazin-6-yl)propanoic acid,

(90) (2E)-3-[7-(1-acryloyl-3-methoxy-3-azetidinyl)-4-amino-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(91) (2E)-3-{4-amino-7-[1-(methylsulfonyl)-4-piperidinyl]-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl}acrylic acid,

(92) (2E)-3-[4-amino-7-cyclopentyl-5-(2-fluoro-4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(93) 3-[4-amino-7-(3-methoxyphenyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]propanoic acid,

(94) (2E)-3-[4-amino-7-cyclohexyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(95) (2E)-3-[4-amino-7-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(96) (2E)-3-(4-amino-7-cyclopentyl-5-{4-[3-(2-propanyl)phenoxy]phenyl}pyrrolo[2,1-f][1,2,4]triazin-6-yl)acrylic acid,

(97) (2E)-3-{4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]-7-cyclopentylpyrrolo[2,1-f][1,2,4]triazin-6-yl}acrylic acid,

(98) (2E)-3-[4-amino-5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(99) (2E)-3-[4-amino-7-(3-hydroxy-3-methylbutyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(100) (2E)-3-[4-amino-7-isopropyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid,

(101) N-{2-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]ethyl}acetamide,

(102) 1-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-1,2-ethanediol,

(103) 4-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-1-hydroxy-2-butanone,

(104) 4-amino-7-cyclopentyl-N-(2-hydroxyethyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide,

(105) 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-N-(1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide,

(106) 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-N-(1H-pyrazol-3-yl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide,

(107) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylamide,

(108) 4-amino-7-cyclopentyl-N-(2-methoxyethyl)-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide,

(109) 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carbohydrazide,

(110) 4-amino-7-cyclopentyl-N-[2-(dimethylamino)ethyl]-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide,

(111) (2E)-3-[4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]-N-(1H-pyrazol-4-yl)acrylamide, or

(112) 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide.

7. The compound according to claim 1 , which is

(1) 5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-7-(3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(2) 5-(4-(3-chlorophenoxy)-3-methoxyphenyl)-7-(3-methoxyphenyl)-6-(3-(pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(3) 7-cycloheptyl-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)-6-(piperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine,

(4) 1-(3-(4-amino-6-chloro-5-(4-(3-chlorophenoxy)-3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one,

(5) 1-(3-(4-amino-6-chloro-5-(4-(3,4-dichlorophenoxy)-3-methoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)piperidin-1-yl)prop-2-en-1-one,

(6) ethyl 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoate,

(7) ethyl (2E)-3-[7-(1-acryloyl-3-methoxy-3-azetidinyl)-4-amino-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylate,

(8) 1-(3-[4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl]-1-pyrrolidinyl)-2-propen-1-one,

(9) 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(10) 1-(3-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-3-methoxy-1-azetidinyl)-2-propen-1-one,

(11) 3-{7-(1-acryloyl-1,2,5,6-tetrahydro-3-pyridinyl)-4-amino-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(12) 3-{7-(1-acryloyl-3-piperidinyl)-4-amino-5-[4-(3,4-dichlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl}propanoic acid,

(13) 1-[5-{4-amino-6-chloro-5-[4-(3-chlorophenoxy)-3-methoxyphenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}-3,6-dihydro-1(2H)-pyridinyl]-2-propen-1-one, or

(14) (2E)-3-[7-(1-acryloyl-3-methoxy-3-azetidinyl)-4-amino-5-(4-phenoxyphenyl)pyrrolo[2,1-f][1,2,4]triazin-6-yl]acrylic acid.

8. A compound of formula (I) of claim 1 , a salt thereof or a solvate thereof, for preventing and/or treating a Btk related disease.

9. A pharmaceutical composition comprising the compound represented by formula (I) of claim 1 , a salt thereof or a solvate thereof.