Method for screening modulators of apoptosis
The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-κB activity. The modulators may be used, for example, in the treatment of NF-κB-mediated diseases, conditions, and injuries.
1. A method of treating a mammal from ionizing radiation induced apoptosis tissue damage comprising administering to a mammal in need thereof a composition comprising flagellin.
2. The method of claim 1 wherein the composition is administered in combination with a radioprotectant.
3. The method of claim 2 wherein the radioprotectant is an antioxidant.
4. The method of claim 3 wherein the antioxidant is selected from the group consisting of amifostine and vitamin E.
5. The method of claim 2 wherein the radioprotectant is a cytokine.
6. The method of claim 5 , wherein the cytokine is stem cell factor.
7. The method of claim 1 wherein the radiation exposure is radiation therapy for treating cancer.
8. The method of claim 1 wherein the composition is administered prior to, together with, or after the treatment.
9. The method of claim 1 , wherein the composition is administered in combination with a growth factor.
10. The method of claim 9 , wherein the growth factor is keratinocyte growth factor.
11. The method of claim 1 , wherein the composition is administered in combination with a steroid.
12. The method of claim 11 , wherein the steroid is 5-adrostenediol.
13. The method of claim 1 , wherein the composition is administered in combination with ammonium trichloro(dioxoethylene-0-0′)tellurate.