IP Library › Granted Patent US 8,795,666
Granted Patent B2
US 8,795,666 · App. 13/762,133 · Granted Aug 5, 2014

Antagonists of IL-23P19 for treatement of atopic dermatitis

Inventors: Madaline Chirica (Dedham, MA); Robert A. Kastelein (Portola Valley, CA); Kevin Moore (Palo Alto, CA); Christi L. Parham (Menlo Park, CA)
Assignee: Merck Sharp & Dohme Corp.
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Quick Facts
Patent No.
US 8,795,666
App. No.
13/762,133
Granted
Aug 5, 2014
Kind
B2
Abstract

Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.

Claims (4)

1. A method of treating a human subject experiencing atopic dermatitis comprising administering an effective amount of an antagonist antibody that specifically binds to a polypeptide comprising the sequence of SEQ ID NO: 6, or an antigen binding fragment thereof.

2. The method of claim 1 , wherein the antibody or antigen binding fragment thereof is a monoclonal antibody or antigen binding fragment thereof.

3. The method of claim 1 , wherein the antibody or antigen binding fragment thereof is a humanized antibody or antigen binding fragment thereof.

4. The method of claim 1 , wherein the antibody or antigen binding fragment thereof comprises an Fab, Fv, or F(ab′) 2 fragment.

Continuity (9)
Continuation 13350641 · Jan 13, 2012
Continuation 13021445 · Feb 4, 2011
Continuation 12834728 · Jul 12, 2010
Continuation 12181152 · Jul 28, 2008
Continuation 10720026 · Nov 21, 2003
Continuation In Part 10667290 · Sep 18, 2003
Division 09853180 · May 10, 2001
Provisional Application 60203426 · May 10, 2000
Related Publication 20130156729A1 · Jun 20, 2013