IP Library › Granted Patent US 8,802,850
Granted Patent B2
US 8,802,850 · App. 12/844,017 · Granted Aug 12, 2014

Cyclopropyl modulators of P2Y12 receptor

Inventors: Tadimeti Rao (San Diego, CA); Chengzhi Zhang (San Diego, CA)
Assignee: Auspex Pharmaceuticals, Inc.
C07D487/04A61K31/519
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Quick Facts
Patent No.
US 8,802,850
App. No.
12/844,017
Granted
Aug 12, 2014
Kind
B2
Abstract

The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.

Claims (6)

1. A compound having the structural formula:

wherein each position represented as D has deuterium enrichment of no less than about 10%.

2. The compound as recited in claim 1 wherein each position represented as D has deuterium enrichment of no less than about 50%.

3. The compound as recited in claim 1 wherein each position represented as D has deuterium enrichment of no less than about 90%.

4. The compound as recited in claim 1 wherein each position represented as D has deuterium enrichment of no less than about 98%.

5. A tablet or capsule comprising a compound as recited in claim 1 together with a pharmaceutically acceptable carrier.

Assignments (2)
CHANGE OF ASSIGNEE ADDRESS Recorded Feb 2, 2021
From: AUSPEX PHARMACEUTICALS, INC.
To: AUSPEX PHARMACEUTICALS, INC.
Reel/Frame 055193/0866 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2014
From: RAO, TADIMETI; ZHANG, CHENGZHI
To: AUSPEX PHARMACEUTICALS, INC.
Reel/Frame 032002/0584 →
Continuity (2)
Provisional Application 61228913 · Jul 27, 2009
Related Publication 20120301458A1 · Nov 29, 2012