Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor
The present invention provides a method for treating a vertebrate subject suffering from a degenerative disc disease by administering an inhibitor of a matrix metalloprotease (MMP) to the subject in an amount effective to treat the subject.
1. A method for slowing progression of a degenerative disc disease in a human subject suffering from the degenerative disc disease which comprises administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a 4-dedimethyltetracycline homolog or analog, in conjunction with a surgical procedure which results in the intervertebral discs of the subject being accessible to the 4-dedimethyltetracycline homolog or analog, wherein said pharmaceutical composition is administered in an amount effective to slow the progression of the degenerative disc disease, wherein the surgical procedure comprises microdiscectomy, and wherein said 4-dedimethyltetracycline homolog or analog is selected from the group consisting of
4-dedimethylaminotetracycline,
4-dedimethylaminosancycline (6-demethyl-6-deoxy-4-dedimethylaminotetracycline),
4-dedimethylaminominocycline (7-dimethylamino-4-dedimethylaminotetracycline), and
4-dedimethylaminodoxycycline (5-hydroxy-6-deoxy-4-dedimethylaminotetracycline);
is present in said pharmaceutical composition at a concentration of 0.1% to 5% by weight of the composition; and is administered in an amount between 0.1 mg/kg and 30 mg/kg body weight of the subject.
2. The method of claim 1 , wherein the amount effective to treat the subject is also effective to reduce pain concomitant with the degenerative disc disease.
3. The method of claim 1 , wherein the pharmaceutically acceptable carrier comprises a biopolymer.
4. The method of claim 3 , wherein the biopolymer comprises hyaluronic acid or a pharmaceutically acceptable salt or ester thereof.
5. The method of claim 1 , wherein the pharmaceutically acceptable carrier comprises a hydrogel.
6. The method of claim 1 , wherein the 4-dedimethyltetracycline homolog or analog is present at a concentration of 0.1% to 1.0% by weight.
7. The method of any of claim 1 , wherein the pharmaceutical composition is administered by means of a needle or a cannula.
8. The method of claim 1 , wherein the amount of the 4-dedimethyltetracycline homolog or analog administered is between 0.3 mg/kg and 10 mg/kg body weight of the subject.
9. The method of claim 1 , wherein the pharmaceutical composition is administered multiple times over a period of 30-180 days.