Isolated protein and compositions comprising the protein
Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH 2 -A-[-X-L-] n -B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than 1. Proteins where each of the n -X- moieties shares sequence identity to each other -X- moiety, the protein is a ‘tandem protein’.
1. A composition comprising an isolated Neisseria meningitidis protein having 80% or greater sequence identity to the amino acid sequence of SEQ ID NO: 19 adsorbed to an aluminum salt adjuvant.
2. A composition comprising an isolated Neisseria meningitidis protein having 80% or greater sequence identity to the amino acid sequence of SEQ ID NO: 19, and an aluminum hydroxyphosphate adjuvant.