IP Library Granted Patent US 8,846,624
Granted Patent B2
US 8,846,624 · App. 12/440,670 · Granted Sep 30, 2014

Modified protein polymers

Inventors: Elliot L. Chaikof (Atlanta, GA); Vincent P. Conticello (Decatur, GA)
Assignee: Emory University
A61L31/047A61L15/32A61L27/227
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Quick Facts
Patent No.
US 8,846,624
App. No.
12/440,670
Granted
Sep 30, 2014
Kind
B2
Abstract

In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the synthetic proteins are elastin-mimetic proteins having improved mechanical characteristics and related methods of making the proteins with the capability of providing precise control over the mechanical properties. Provided are proteins used in a number of medical devices such as artificial blood vessels, shunts, stents or as embolic agents in situations where it is desired to stop or reduce blood flow or pressure in a localized region.

Claims (4)

1. A synthetic protein comprising SEQ ID NO:33.

2. A synthetic protein comprising SEQ ID NO:26.

3. A recombinant nucleic acid sequence that encodes a protein comprising SEQ ID NO: 33.

4. A recombinant nucleic acid sequence that encodes a protein comprising SEQ ID NO: 26.

Assignments (2)
CONFIRMATORY LICENSE Recorded May 28, 2010
From: EMORY UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024454/0384 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2009
From: CHAIKOF, ELLIOT L.; CONTICELLO, VINCENT P.
To: EMORY UNIVERSITY
Reel/Frame 022531/0192 →
Continuity (3)
Provisional Application 60825255 · Sep 11, 2006
Provisional Application 60863117 · Oct 26, 2006
Related Publication 20100048473A1 · Feb 25, 2010