Azaindazoles as kinase inhibitors and use thereof
Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A 1 , A 2 , A 3 , R 4 are as defined herein.
1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein
A 1 is selected from N and CR 1 ;
A 2 is selected from N and CR 2 ;
A 3 is selected from N and CR 3 ; wherein at least one of A 1 , A 2 , and A 3 is N; and A 1 and A 2 are not simultaneously N;
R 1 is selected from H, F, Cl, Br, NO 2 , CN, NR a R a , C 1-6 alkyl substituted with 0-5 R 1a , C 2-6 alkenyl substituted with 0-5 R 1a , C 2-6 alkynyl substituted with 0-5 R 1a , —O—C 1-6 alkyl, —O—(CHR) r -carbocyclyl substituted with 0-5 R 1a , —(CHR) r -carbocyclyl substituted with 0-5 R 1a , and —(CHR) r -heterocyclyl substituted with 0-5 R 1a ;
R 1a , at each occurrence, is independently selected from C 1-6 alkyl substituted with 0-5 R e , C 2-6 alkenyl substituted with 0-5 R e , C 2-6 alkynyl substituted with 0-5 R e , C 1-6 haloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)R d , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r NR a P(O) p R b , —(CHR) r —C 3-6 -carbocyclyl substituted with 0-5 R e and/or —(CHR) r -heterocyclyl substituted with 0-5 R e ;
R 2 is selected from H, F, Cl, Br, NO 2 , CN, NR a R a , C 1-6 alkyl substituted with 0-5 R 2a , C 2-6 alkenyl substituted with 0-5 R 2a , C 2-6 alkynyl substituted with 0-5 R 2a , —O—C 1-6 alkyl substituted with 0-5 R 2a , —O—(CHR) r -carbocyclyl substituted with 0-5 R 2a , —(CHR) r -carbocyclyl substituted with 0-5 R 2a , and —(CHR) r -heterocyclyl substituted with 0-5 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —(CH 2 ) r C 3-10 -cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)NR a R a , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r C(O)C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r C(O)NR a S(O) p R b , —(CHR) r C(O)NR a (CHR) r C(O)OR d , —(CHR) r -carbocyclyl substituted with 0-5 R e and/or —(CHR) r -heterocyclyl substituted with 0-5 R e ;
R 3 is selected from H, F, Cl, Br, NO 2 , CN, C 1-6 alkyl substituted with 0-5 R 3a , C 2-6 alkenyl substituted with 0-5 R 3a , C 2-6 alkynyl substituted with 0-5 R 3a , —O—C 1-6 alkyl substituted with 0-5 R 3a , —O-carbocyclyl substituted with 0-5 R 3a , —(CHR) r -carbocyclyl substituted with 0-5 R 3a and —(CHR) r -heterocyclyl substituted with 0-5 R 3a ;
R 3a , at each occurrence, is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —(CH 2 ) r C 3-10 cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r —O—(CHR) r R b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)R d , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r -aryl substituted with 0-5 R e , and/or —(CHR) r -heterocyclyl substituted with 0-5 R e ;
alternatively, R 1 and R 2 , or R 2 and R 3 , are taken together with the ring atoms to which they are attached to form a fused carbocyclyl or heterocyclyl;
R 4 is selected from carbocyclyl substituted with 0-5 R 4a and heterocyclyl substituted with 0-5 R 4a ;
R 4a , at each occurrence, is independently selected from F, Cl, Br, NO 2 , CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —(CHR) r OH, —(CHR) r SH, —(CHR) r —O—(CHR) r R c , —(CHR) r S(O) p (CHR) r R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)R d , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r C 3-6 -carbocyclyl substituted with 0-5 R e , and/or —(CHR) r -heterocyclyl substituted with 0-5 R e ;
R, at each occurrence, is independently selected from H, C 1-6 alkyl, C 1-6 haloalkyl, and/or —(CH 2 ) r -aryl;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-6 alkyl substituted with 0-3 R e , C 2-6 alkenyl substituted with 0-3 R e , C 2-6 alkynyl substituted with 0-3 R e , C 1-6 haloalkyl, —O—C 1-6 alkyl substituted with 0-3 R e , —(CH 2 ) r OH, (CH 2 ) r C 3-10 carbocyclyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e , or R a and R a , together with the nitrogen atom to which they are both attached, form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-6 alkyl substituted with 0-3 R e , C 1-6 haloalkyl, C 2-6 alkenyl substituted with 0-3 R e , C 2-6 alkynyl substituted with 0-3 R e , —(CH 2 ) r C 3-10 -carbocyclyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R c , at each occurrence, is independently selected from C 1-6 alkyl substituted with 0-3 R g , C 2-6 alkenyl substituted with 0-3 R g , C 2-6 alkynyl substituted with 0-3 R g , C 1-6 haloalkyl, —(CH 2 ) r OH, —(CH 2 ) r —C 3-10 carbocyclyl substituted with 0-3 R g , and/or —(CH 2 ) r heterocyclyl substituted with 0-3 R g ;
R d , at each occurrence, is independently selected from H, C 1-6 alkyl substituted with 0-3 R e , C 1-6 haloalkyl, C 2-6 alkenyl substituted with 0-3 R e , C 2-6 alkynyl substituted with 0-3 R e , —(CH 2 ) r —C 3-10 carbocyclyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —(CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r CO 2 H, —(CH 2 ) r OC 1-5 alkyl, OH, SH, —(CH 2 ) r SC 1-5 alkyl, —(CH 2 ) r NR f R f , —(CH 2 ) r C(O)NR f R f , —(CH 2 ) r -phenyl, and/or —(CH 2 ) r -heterocyclyl;
R f , at each occurrence, is independently selected from H, C 1-5 alkyl, and C 3-6 cycloalkyl, and/or phenyl;
R g , at each occurrence, is independently selected from C 1-6 alkyl, (CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r CO 2 H, —(CH 2 ) r OC 1-6 alkyl, OH, —(CH 2 ) r -phenyl, and/or —(CH 2 ) r -heterocyclyl;
p, at each occurrence, is independently selected from 0, 1, and/or 2;
r, at each occurrence, is independently selected from 0, 1, 2, 3, and/or 4;
provided that:
(1) if A 1 is N, A 2 is CR 2 , and A 3 is N, then R 4 is phenyl substituted with 1-4 R 4a wherein at least one R 4a is —O—(CHR) r -phenyl substituted with 0-5 R g ;
(2) if A 1 is N, A 2 is CR 2 , and A 3 is CR 3 , then R 4 is phenyl substituted with 1-4 R 4a wherein at least one R 4a is —O—(CHR) r -phenyl substituted with 0-5 R g and R 2 is other than C 1-6 alkyl, cyclohexyl, or 1,4-dioxaspiro[4,5]dec-8-yl each substituted or unsubstituted; and
(3) if A 1 is CR 1 , A 2 is N, A 3 is CR 3 , and R 4a is NH 2 or phenyl, then R 1 is not hydrogen.
2. The compound according to claim 1 of the Formula (II) or (III):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is selected from H, F, Cl, Br, NR a R a , C 1-4 alkyl substituted with 0-3 R 1a , —O—C 1-4 alkyl, —O-aryl substituted with 0-3 R 1a , —(CHR) r -aryl substituted with 0-3 R 1a , —(CHR) r -heterocyclyl substituted with 0-3 R 1a ;
R 1a , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , C 1-4 haloalkyl, F, Cl, Br, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)R d , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r —C 3-6 -carbocyclyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R 2 is selected from H, F, Cl, Br, NO 2 , CN, NR a R a , C 1-4 alkyl substituted with 0-3 R 2a , —O—C 1-4 alkyl substituted with 0-3 R 2a , —O-carbocyclyl substituted with 0-3 R 2a , —(CHR) r -carbocyclyl substituted with 0-3 R 2a , and heterocyclyl substituted with 0-3 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 haloalkyl, —(CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)NR a R a , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r C(O)C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r C(O)NR a S(O) p R b , —(CHR) r C(O)NR a (CHR) r C(O)OR d , —(CHR) r -carbocyclyl substituted with 0-3 R e and/or —(CHR) r -heterocyclyl substituted with 0-3 R e ;
alternatively, R 1 and R 2 of Formula (III) are taken together with the ring atoms to which they are attached to form a fused carbocyclyl or heterocyclyl;
R 3 is selected from H, F, Cl, Br, NO 2 , CN, C 1-4 alkyl substituted with 0-3 R 3a , —O—C 1-4 alkyl substituted with 0-3 R 3a , —O-aryl substituted with 0-3 R 3a , —(CHR) r -aryl substituted with 0-3 R 3a , and —(CHR) r -heterocyclyl substituted with 0-3 R 3a ;
R 3a , at each occurrence, is independently selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 -haloalkyl, —(CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r —O—(CHR) r R b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)R d , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r -aryl substituted with 0-3 R e , and/or —(CHR) r -heterocyclyl substituted with 0-3 R e ;
R 4 is selected from aryl substituted with 0-3 R 4a and heterocyclyl substituted with 0-3 R 4a ;
R 4a , at each occurrence, is independently selected from F, Cl, Br, C 1-4 alkyl, —(CHR) r OH, —(CHR) r OR e , —(CHR) r SR b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r NHC(O)R d —(CHR) r C(O)NR a R a , —(CHR) r —C 3-6 carbocyclyl substituted with 0-3 R e , and/or —(CHR) r -heterocyclyl substituted with 0-3 R e ,
R, at each occurrence, is independently selected from H, C 1-6 alkyl, and/or C 1-6 haloalkyl;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-4 alkyl substituted with 0-3 R e , CF 3 , —O—C 1-4 alkyl, —(CH 2 ) r OH, —(CH 2 ) r C 3-6 cycloalkyl substituted with 0-3 R e , —(CH 2 ) r -phenyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e , or R a and R a together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , CF 3 , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R c , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R g , C 2-4 alkenyl substituted with 0-3 R g , C 2-4 alkynyl substituted with 0-3 R g , C 1-4 -haloalkyl, —(CH 2 ) r OH, —(CH 2 ) r -aryl substituted with 0-3 R g , —(CH 2 ) r —C 3-10 cycloalkyl substituted with 0-3 R g and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R g ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl substituted with 0-3 R e , C 2-4 alkenyl substituted with 0-3 R e , C 2-4 alkynyl substituted with 0-3 R e , CF 3 , —(CH 2 ) r -phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-4 alkyl, C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r CO 2 H; —(CH 2 ) r C(O)NR f R f ; —(CH 2 ) r OC 1-4 alkyl, OH, SH, —(CH 2 ) r SC 1-5 alkyl, —(CH 2 ) r -phenyl, and/or —(CH 2 ) r -heterocyclyl;
R f , at each occurrence, is independently selected from H and/or C 1-5 alkyl;
R g , at each occurrence, is independently selected from C 1-4 alkyl, —(CH 2 ) r —C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r OC 1-4 alkyl, OH, and/or —(CH 2 ) r phenyl; and
r, at each occurrence, is independently selected from 0, 1, 2, and/or 3.
3. The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein
R 1 is —NH-aryl substituted with 0-3 R e ;
R 4 is selected from aryl substituted with 0-3 R 4a and heterocyclyl substituted with 0-3 R 4a ;
R 4a , at each occurrence, is independently selected from —(CH 2 ) r OH, —OR e , C 1-4 alkyl, —NHC(O)R d , —C(O)NHR a , NR a R a , and/or —(CH 2 ) r SR b ;
R a , at each occurrence, is independently selected from H, NH 2 , and/or C 1-4 alkyl substituted with 0-3 R e ;
R c , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R g and/or aryl substituted with 0-3 R g ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl substituted with 0-3 R e , and/or phenyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from F, Cl, Br, and C 1-4 alkyl; and
R g , at each occurrence, is independently selected from F, Cl, Br, OH, and/or C 1-4 alkyl.
4. The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein
R 4 is substituted with 0-3 R 4a and selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, furyl, thienyl, piperidinyl, pyridyl, pyrazinyl, pyrimidinyl, triazolyl, indolyl, indazolyl, benzothiazolyl, benzoxazolyl, benzodioxolyl, benzothienyl, quinolinyl, isoquinolinyl, benzimidazolyl, benzofuryl, benzisothiazolyl, benzisoxazolyl, benzodiazinyl, and dibenzothienyl.
5. The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein
R 4 is selected from naphthyl and phenyl, each of which is substituted with 1-3 R 4a and;
R 4a , at each occurrence, is independently selected from F, Cl, Br, C 1-4 alkyl, —(CH 2 ) r OH, —(CH 2 ) r OR, and/or —(CH 2 ) r SR b .
6. The compound according to claim 5 of the Formula (IIa) or (IIIa):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is selected from H, NHR a , C 1-4 alkyl substituted with 0-3 R 1a , —O—C 1-4 alkyl, —O-aryl substituted with 0-3 R 1a , —(CH 2 ) r aryl substituted with 0-3 R 1a , heterocyclyl substituted with 0-3 R 1a ;
R 1a , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , C 1-4 -haloalkyl, F, Cl, Br, —(CH 2 ) r OH, —(CH 2 ) r SH, —(CH 2 ) r OR b , —(CH 2 ) r S(O) 2 R b , —(CH 2 ) r C(O)R d , —(CHANR a R a , —(CH 2 ) r C(O)NR a R a , —(CH 2 ) r C(O)NHOR b , —(CH 2 ) r NHC(O)R d , —(CH 2 ) r NHC(O)OR b , —(CH 2 ) r OC(O)NR a R a , —(CH 2 ) r C(O)OR d , —(CH 2 ) r S(O) 2 NR a R a , —(CH 2 ) r NHS(O) 2 R b , —(CH 2 ) r NHP(O) p R b , —(CH 2 ) r -phenyl substituted with 0-3 R e and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R 2 is selected from H, F, Cl, Br, NO 2 , CN, NR a R a , C 1-4 alkyl substituted with 0-3 R 2a , —O—C 1-4 alkyl substituted with 0-3 R 2a , —O-aryl substituted with 0-3 R 2a , —(CH 2 ) r -phenyl substituted with 0-3 R 2a , —(CH 2 ) r —C 3-10 cycloalkyl substituted with 0-3 R 2a , and heterocyclyl substituted with 0-3 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-4 alkyl, C 1-4 -haloalkyl, F, Cl, Br, NO 2 , CN, —(CH 2 ) r OH, —(CH 2 ) r SH, —(CH 2 ) r OR b , —(CH 2 ) r S(O) p R b , —(CH 2 ) r C(O)R d , —(CH 2 ) r NR a R a , —(CH 2 ) r C(O)NR a R a , —(CH 2 ) r C(O)NR a OR b , —(CH 2 ) r NHC(O)NR a R a , —(CH 2 ) r NHC(O)OR b , —(CH 2 ) r OC(O)NR a R a , —(CH 2 ) r C(O)OR d , —(CH 2 ) r C(O)C(O)OR d , —(CH 2 ) r S(O) 2 NR a R a , —(CH 2 ) r NHS(O) 2 R b , —(CH 2 ) r C(O)NHS(O) 2 R b , —(CH 2 ) r C(O)NR a (CH 2 ) r C(O)OR d , —(CH 2 ) r C 3-6 cycloalkyl, —(CH 2 ) r phenyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R 3 is selected from H, C 1-4 alkyl substituted with 0-3 R 3a , aryl substituted with 0-3 R 3a , and heterocyclyl substituted with 0-3 R 3a ;
R 3a , at each occurrence, is independently selected from C 1-4 alkyl, C 1-4 -haloalkyl, —(CH 2 ) r OH, —(CH 2 ) r OR b , —(CH 2 ) r S(O) 2 R b , —(CH 2 ) r C(O)R d , —(CH 2 ) r NR a R a , —(CH 2 ) r C(O)NR a R a , —(CH 2 ) r NHC(O)R d , —(CH 2 ) r NHC(O)OR b , —(CH 2 ) r C(O)OR d , —(CH 2 ) r -phenyl substituted with 0-3 R e and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-4 alkyl substituted with 0-3 R e , CF 3 , —O—C 1-4 alkyl, —(CH 2 ) r OH, —(CH 2 ) r C 3-6 cycloalkyl substituted with 0-3 R e , —(CH 2 ) r phenyl substituted with 0-3 R e , and/or —(CH 2 ) r heterocyclyl substituted with 0-3 R e , or R a and R a together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R g , C 1-4 -haloalkyl, —(CH 2 ) r —C 3-6 cycloalkyl substituted with 0-3 R g , —(CH 2 ) r -aryl substituted with 0-3 R g and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R g ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl substituted with 0-3 R e , C 2-4 alkenyl substituted with 0-3 R e , —(CH 2 ) r phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-4 alkyl, C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r CO 2 H, —(CH 2 ) r C(O)NR/(C 1-4 alkyl), —(CH 2 ) r OC 1-5 alkyl, OH, SH, —(CH 2 ) r SC 1-4 alkyl, —(CH 2 ) r phenyl and/or —(CH 2 ) r heterocyclyl;
R g , at each occurrence, is independently selected from C 1-4 alkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r OC 1-4 alkyl, OH, and/or —(CH 2 ) r phenyl;
r, at each occurrence, is independently selected from 0, 1, and/or 2; and
n, at each occurrence, is independently selected from 0, 1, and/or 2.
7. The compound according to claim 6 of the Formula (IIb) or (IIIb):
or a pharmaceutically acceptable salt thereof, wherein
R 1 is selected from H, NHR a , C 1-4 alkyl substituted with 0-3 R 1a , —O—C 1-4 alkyl, —(CH 2 ) r aryl substituted with 0-3 R 1a , and heterocyclyl substituted with 0-3 R 1a ;
R 1a , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , CF 3 , F, Cl, Br, —(CH 2 ) r OH, —(CH 2 ) r OR b , —(CH 2 ) r S(O) 2 R b , —(CH 2 ) r C(O)R d , —(CH 2 ) r NR a R a , —(CH 2 ) r C(O)NR a R a , —(CH 2 ) r NHC(O)R d , —(CH 2 ) r NHC(O)OR b , —(CH 2 ) r C(O)OR d , —(CH 2 ) r S(O) 2 NR a R a , —(CH 2 ) r NHS(O) 2 R b , —(CH 2 ) r -phenyl substituted with 0-3 R e and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R 2 is selected from H, F, Cl, Br, NHR a , C 1-4 alkyl substituted with 0-3 R 2a , —(CH 2 ) r -aryl substituted with 0-3 R 2a , —(CH 2 ) r —C 3-10 cycloalkyl substituted with 0-3 R 2a , and heterocyclyl substituted with 0-3 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-4 alkyl, C 1-4 -haloalkyl, F, Cl, Br, NO 2 , CN, —(CH 2 ) r OH, —(CH 2 ) r OR b , —(CH 2 ) r C(O)R d , —(CH 2 ) r NR a R a , —(CH 2 ) r C(O)NR a R a , —(CH 2 ) r NHC(O)NR a R a , —(CH 2 ) r C(O)OR d , —(CH 2 ) r C(O)C(O)OR d , —(CH 2 ) r C(O)NHS(O) 2 R b , —(CH 2 ) r C(O)NR a (CH 2 ) r C(O)OR d , —(CH 2 ) r phenyl substituted with 0-3 R e , and/or —(CH 2 ) r -heterocyclyl substituted with 0-3 R e ;
R 3 is selected from H, C 1-4 alkyl substituted with 0-3 R 3a , phenyl substituted with 0-3 R 3a , and heterocyclyl substituted with 0-3 R 3a ;
R 3a , at each occurrence, is independently selected from —(CH 2 ) r OR b and —(CH 2 ) r C(O)NR a R a ;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-4 alkyl substituted with 0-3 R e , —(CH 2 ) r OH, —(CHAC 3-6 cycloalkyl substituted with 0-3 R e , —(CH 2 ) r phenyl substituted with 0-3 R e , and/or —(CH 2 ) r heterocyclyl substituted with 0-3 R e , or R a and R a together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-4 alkyl substituted with 0-3 R e , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl substituted with 0-3 R e , C 2-4 alkenyl substituted with 0-3 R e , —(CH 2 ) r phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from F, Cl, C 1-4 alkyl, —(CH 2 ) r CO 2 H, and/or —(CH 2 ) r C(O)N(CH 3 ) 2 ,
R g , at each occurrence, is independently selected from F, Cl, Br, OH, C 1-4 alkyl, and/or —OC 1-4 alkyl;
r, at each occurrence, is independently selected from 0, 1, and/or 2; and
n, at each occurrence, is independently selected from 0, 1, and/or 2.
8. The compound according to claim 1 of the Formula (IV):
or a pharmaceutically acceptable salt thereof, wherein
R 2 is selected from H, —O-aryl wherein said aryl is substituted with 0-3 R 2a , —O—C 1-4 alkyl wherein said alkyl is substituted with 0-3 R 2a , NR a R a , C 3-6 cycloalkyl substituted with 0-3 R 2a , aryl substituted with 0-3 R 2a , and heterocyclyl substituted with 0-3 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, —(CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r NR a C(O)NR a R a , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r C(O)NR a S(O) p R b , —(CHR) r C(O)NR a (CHR) r C(O)OR d , —(CHR) r -aryl substituted with 0-5 R e and/or —(CHR) r -heterocyclyl substituted with 0-5 R e ;
R 3 is selected from H, F, Cl, Br, NO 2 , CN, C 1-4 alkyl, —(CHR) r -aryl substituted with 0-3 R 3a , —O—C 1-4 alkyl, —O-aryl substituted with 0-3 R 3a , and —(CHR) r heterocyclyl substituted with 0-3 R 3a ;
R 3a , at each occurrence, is selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 -haloalkyl, —(CH 2 ) r C 3-6 cycloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-4 alkyl substituted with 0-3 R e , CF 3 , —O—C 1-6 alkyl, —(CH 2 ) r OH, C 3-6 cycloalkyl substituted with 0-3 R e , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e , or R a and R a together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-4 alkyl, CF 3 , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl, CF 3 , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-4 alkyl, C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , NH 2 , CO 2 H, —(CH 2 ) r OC 1-5 alkyl, OH, SH, (CH 2 ) r SC 1-5 alkyl, (CH 2 ) r phenyl and/or (CH 2 ) r heterocyclyl;
R g , at each occurrence, is independently selected from C 1-4 alkyl, F, Cl, Br, CN, NO 2 , —(CH 2 ) r OC 1-4 alkyl, and/or OH;
r, at each occurrence, is independently selected from 0, 1, and/or 2; and
n, at each occurrence, is independently selected from 0, 1, 2, and/or 3.
9. The compound according to claim 8 or a pharmaceutically acceptable salt thereof, wherein
R 2 is selected from C 3-6 cycloalkyl, —NH—C 3-6 cycloalkyl, —O-phenyl, phenyl, pyrrole, piperidine, piperazine, and pyridine, each ring substituted with 0-2 R 2a ; and
R 2a , at each occurrence, is independently selected from —O—C 1-4 alkyl, OH, NH 2 , —NHC(O)O—C 1-4 alkyl, —NHC(O)NH-heteroaryl, —NHC(O)-phenyl unsubstituted or substituted with C 1-4 alkyl, —C(O)—C 1-4 alkyl, —C(O)-phenyl, —C(O)NH-phenyl, —C(O)NH—C 3-6 cycloalkyl, —C(O)NH-heterocyclyl, —C(O)NH—NH 2 , and/or —C(O)NR a R a wherein R a and R a may be taken together with the nitrogen atom to which they are attached to form a 5- to 6-membered heterocyclyl.
10. The compound according to claim 1 of the Formula (V):
or a pharmaceutically acceptable salt thereof, wherein
R 2 is selected from H, F, Cl, Br, NO 2 , CN, NR a R a , C 1-6 alkyl, —(CHR) r -carbocyclyl substituted with 0-5 R 2a , —O—C 1-6 alkyl, —O—(CHR) r -carbocyclyl substituted with 0-5 R 2a , heterocyclyl substituted with 0-5 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 -haloalkyl, F, Cl, Br, NO 2 , CN, —(CHR) r OH, —(CHR) r SH, —(CHR) r OR b , —(CHR) r S(O) p R b , —(CHR) r C(O)R d , —(CHR) r NR a R a , —(CHR) r C(O)NR a R a , —(CHR) r C(O)NR a OR b , —(CHR) r NR a C(O)NR a R a , —(CHR) r NR a C(O)OR b , —(CHR) r OC(O)NR a R a , —(CHR) r C(O)OR d , —(CHR) r S(O) p NR a R a , —(CHR) r NR a S(O) p R b , —(CHR) r C(O)NR a S(O) p R b , —(CHR) r C(O)NR a (CHR) r C(O)OR d , —(CHR) r C 3-6 -carbocyclyl substituted with 0-3 R e and/or —(CHR) r C 3-6 heterocyclyl substituted with 0-3 R e ;
Q is selected from aryl and heteroaryl;
R 4a is selected from F, Cl, Br, OH, and C 1-6 alkyl;
R a , at each occurrence, is independently selected from H, NH 2 , C 1-4 alkyl substituted with 0-3 R e , CF 3 , —O—C 1-6 alkyl, —(CH 2 ) r OH, C 3-6 cycloalkyl substituted with 0-3 R e , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e , or R a and R a together with the nitrogen atom to which they are both attached form a heterocyclyl substituted with 0-3 R e ;
R b , at each occurrence, is independently selected from C 1-4 alkyl, CF 3 , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R c is selected from C 3-6 cycloalkyl substituted with 0-3 R g , aryl substituted with 0-3 R g , and heterocyclyl substituted with 0-3 R g ;
R d , at each occurrence, is independently selected from H, C 1-4 alkyl, CF 3 , phenyl substituted with 0-3 R e , and/or heterocyclyl substituted with 0-3 R e ;
R e , at each occurrence, is independently selected from C 1-4 alkyl, C 3-6 cycloalkyl, F, Cl, Br, CN, NO 2 , CO 2 H, —(CH 2 ) r OC 1-5 alkyl, OH, SH, —(CH 2 ) r SC 1-5 alkyl, —(CH 2 ) r phenyl and/or —(CH 2 ) r heterocyclyl;
R g , at each occurrence, is independently selected from F, Cl, Br, OH, C 1-6 alkyl, and/or —OC 1-5 alkyl;
n, at each occurrence, is independently selected from 0, 1, and/or 2; and
r, at each occurrence, is independently selected from 0, 1, and/or 2.
11. The compound according to claim 10 or a pharmaceutically acceptable salt thereof, wherein
Q is phenyl;
R 2 is selected from F, Cl, Br, NO 2 , CN, NR a R a , —(CHR) r —C 3-10 cycloalkyl substituted with 0-3 R 2a , —(CHR) r -aryl substituted with 0-3 R 2a —O—C 1-4 alkyl, —O—(CHR) r -aryl substituted with 0-3 R 2a , and heterocyclyl substituted with 0-3 R 2a ;
R 2a , at each occurrence, is independently selected from C 1-4 alkyl, C 1-4 -haloalkyl, F, Cl, Br, NO 2 , CN, —OH, —SH, —OR b , —S(O) 2 R b , —C(O)R d , —NR a R a , —C(O)NR a R a ;
—C(O)NR a OR b , —NHC(O)NR a R a , —NHC(O)OR b , —OC(O)NR a R a , —C(O)OR d , —S(O) 2 NR a R a , —NHS(O) 2 R b , —C(O)NHS(O) 2 R b , —C(O)NR a (CH 2 ) r C(O)OR d , C 3-6 cycloalkyl substituted with 0-3 R e , phenyl substituted with 0-3 R e and/or heterocyclyl substituted with 0-3 R e ;
R c is phenyl substituted with 0-3 R g ; and
r, at each occurrence, is independently selected from 0 and/or 1.
12. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.
13. The compound according to claim 8 or a pharmaceutically acceptable salt thereof, wherein said compound is: 6-cyclopentyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (1); 4-(4-(benzyloxy)phenyl)-6-cyclopentyl-1H-pyrazolo[3,4-b]pyridin-3-amine (2); 6-cyclopentyl-4-(4-(2-methylphenoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (3); 6-cyclopentyl-4-(4-(4-methylphenoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (4); 6-cyclopentyl-4-(4-(3-methylphenoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (5); 4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (6); 6-cyclohexyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (7); 6-(4-methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (8); 4-(4-phenoxyphenyl)-6-(1-piperidinyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (9); 6-phenoxy-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (10); 4-(4-phenoxyphenyl)-6-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (11); 6-(3-methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (12); 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)benzoic acid (13); 1-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl)ethanone (14); 4-(4-phenoxyphenyl)-6-(1-pyrrolidinyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (15); N 6 -cyclopentyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridine-3,6-diamine (16); tert-butyl(1-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-3-pyrrolidinyl) carbamate (17); tert-butyl(1-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-piperidinyl)carbamate (18); 6-(4-benzoyl-1-piperazinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (19); 6-(4-methoxyphenoxy)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (20); 6-methoxy-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (21); 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol (22); 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenol (23); N-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl)acetamide (24); 6-(3-aminophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (25); 6-(3-amino-1-pyrrolidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (26); 1-(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl)-3-(4-methyl-1,3-thiazol-2-yl)urea (27); 6-(4-aminophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (28); N-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl)acetamide (29); 6-(4-amino-1-piperidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (30); 1-(1-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-3-pyrrolidinyl)-3-(4-methyl-1,3-thiazol-2-yl)urea (31); 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)benzohydrazide (33); 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-N-phenylbenzamide (34); 6-(3-(4-morpholinylcarbonyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (35); 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-N-cyclopropylbenzamide (36); or 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-N-1H-indol-2-ylbenzamide (37).
14. The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein said compound is: 4-(2-Naphthyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (38); 4-(4-Methoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (39); 4-(3-Methoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (40); 4-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (41); 4-(1,3-Benzodioxol-5-yl)-1H-pyrazolo[3,4-c]pyridin-3-amine (42); 4-(4-Isopropoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (43);
4-(4-(Cyclopentyloxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (44); 4-(4-(Methylsulfanyl)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (45); 4-(4-(Trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (46); 4-(4-(1-Pyrrolidinylcarbonyl)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (47); 4-Dibenzo[b,d]thiophen-2-yl-1H-pyrazolo[3,4-c]pyridin-3-amine (48); 4-(6-Methoxy-2-naphthyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (49); 4-(4-(4-Methoxyphenoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (50); 4-(4-(3-Methoxyphenoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (51); 4-(4-(3-Ethoxyphenoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (52); 4-(4-(3,5-Dimethylphenoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (53); 4-(3-Amino-1H-pyrazolo[3,4-c]pyridin-4-yl)-2-methylphenol (54); 4-(3-Methyl-4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (55); 4-(3-Fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (56); 4-(4-(3-Amino-1H-pyrazolo[3,4-c]pyridin-4-yl)phenoxy)phenol (57); 4-(4-Benzylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (58); 4-(4-Phenoxyphenyl)-7-phenyl-1H-pyrazolo[3,4-c]pyridin-3-amine (59); 7-(4-(4-Morpholinylcarbonyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (60); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenyl)benzamide (61); N-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenyl)methanesulfonamide (62); 4-(4-Phenoxyphenyl)-7-(4-(1-pyrrolidinylcarbonyl)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (63); 7-(3-(Methylsulfonyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (64); 7-(3-(Methoxymethyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (65); tert-Butyl(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)carbamate (66); 4-(4-Phenoxyphenyl)-7-(2-pyridinyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (67); 4-(4-Phenoxyphenyl)-7-(2-pyrazinyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (68); 4-(4-Phenoxyphenyl)-5-(4-(1-pyrrolidinylcarbonyl)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (69); 4,5-Bis(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (70); 7-(4-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (71); 5-(4-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (72); N-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide (73); 7-(3-(Aminomethyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (74);
N-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)benzamide (75); N-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)methanesulfonamide (76); N-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)benzenesulfonamide (77); 7-Hydrazino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (78); 4-(4-Phenoxyphenyl)-7-(4-phenyl-1H-pyrazol-1-yl)-1H-pyrazolo[3,4-c]pyridin-3-amine (79); 4-(4-Phenoxyphenyl)-7-(1H-1,2,4-triazol-1-yl)-1H-pyrazolo[3,4-c]pyridin-3-amine (80); 4-(4-Phenoxyphenyl)-7-(1H-pyrazol-1-yl)-1H-pyrazolo[3,4-c]pyridin-3-amine (81); 7-(3,4-Dichlorophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (82); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzoic acid (83); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzoic acid (84); 7-(3-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (85); 7-Dibenzo[b,d]furan-1-yl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (86); 4-(4-Phenoxyphenyl)-7-(6-quinolinyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (87); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)-N,N-dimethylbenzamide (88); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)-N-(2-furylmethyl)benzamide (89); 7-(1,3-Benzodioxol-5-yl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (90); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenol (91); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenol (92); (3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenyl)methanol (93); 7-(3-(Dimethylamino)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (94);
7-(1H-Indol-5-yl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (95); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenyl) methanesulfonamide (96); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzamide (97); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzamide (98); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)acetamide (99); 4,7-Bis(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (100); 7-(3,5-Dimethylphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (101); 7-(3-Isobutoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (102); 3-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)phenyl) propanoic acid (103); 7-(3,4-Dimethoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (104); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzyl)methanesulfonamide (105); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-7-yl)benzenesulfonamide (106); 7-(2-Methylphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (107); 4-(4-Phenoxyphenyl)-7-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (108); 7-(2-Naphthyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (109); 7-(2,3-Dihydro-1-benzofuran-5-yl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (110); 7-(4-Isobutoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (111); 4-(4-Phenoxyphenyl)-7-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (112); 4-(4-Phenoxyphenyl)-7-(3-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-c]pyridin-3-amine (113); 4-(3-Methoxyphenyl)-N 7 -phenyl-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (128); 4-(3-Methoxyphenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (129); N 7 -(2-Chlorophenyl)-4-(3-methoxyphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (130); 3-(3-Amino-7-((2-methylphenyl)amino)-1H-pyrazolo[3,4-c]pyridin-4-yl)phenol (131); 4-(4-Methoxyphenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (132); N-((3R)-1-(3-Amino-7-((2-methylphenyl)amino)-1H-pyrazolo[3,4-c]pyridin-4-yl)-3-piperidinyl)benzamide (133); 4-(2-Methoxy-4-pyridinyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (134); 4-(3-Ethoxyphenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (135); N 7 -(2-Methylphenyl)-4-phenyl-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (136); 4-(3-Isopropoxyphenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (137); 4-(1H-Indazol-5-yl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (138); 3-(3-Amino-7-((2-methylphenyl)amino)-1H-pyrazolo[3,4-c]pyridin-4-yl)-N-methylbenzamide (139); 4-(2-Methoxyphenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (140); 4-(3-Amino-7-((2-methylphenyl)amino)-1H-pyrazolo[3,4-c]pyridin-4-yl)-N-methylbenzamide (141); N 7 -(2-Methylphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (142); N 7 -(2-Methylphenyl)-4-(2-naphthyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (143); 4-(3-Aminophenyl)-N 7 -(2-methylphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (144); N 7 -(2-Methylphenyl)-4-(3-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (145); (3-(3-Amino-7-((2-methylphenyl)amino)-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl)methanol (146); N 4 -(2-Methylphenyl)-7-(6-quinolinyl)-1H-pyrazolo[4,3-c]pyridine-3,4-diamine (147); N 7 -(2-Methylphenyl)-4-(2-pyridinyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (148); N 7 -(2-Methylphenyl)-4-(1-piperidinyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (149); N 7 -(2,4-Dimethylphenyl)-4-(3-methoxyphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (150); or N 7 -Mesityl-4-(3-methoxyphenyl)-1H-pyrazolo[3,4-c]pyridine-3,7-diamine (151).
15. The compound according to claim 2 or a pharmaceutically acceptable salt thereof, wherein said compound is: 6-(4-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (152); 6-(3-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (153); 6-(3-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (154); 6-(2-Naphthyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (155); 6-(2-Naphthyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (156); 6-(1-Benzyl-1H-pyrazol-4-yl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (157); 4-(4-Phenoxyphenyl)-6-(4-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (158); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenol (159); 4-(4-Phenoxyphenyl)-7-phenyl-1H-pyrazolo[4,3-c]pyridin-3-amine (160); 6-Chloro-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (161); 6-Chloro-7-methyl-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (162); 6-Chloro-7-methoxy-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (163); 4-(4-Phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (164); 7-Methyl-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (165); 7-Methoxy-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (166); 7-Benzyl-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (167); 4-(4-Phenoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-amine (168); (1-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-pyrrolidinyl)methanol (169); (1-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-3-piperidinyl)methanol (170); (1-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-4-piperidinyl)methanol (171); 6-(3-Bromophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (172); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzonitrile (173); 6-(3-Nitrophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (174); 4-(4-Phenoxyphenyl)-6-(3-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (175); 6-(4-(Dimethylamino)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (176); 4-(4-Phenoxyphenyl)-6-(2-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (177); 6-(5-Bromo-3-pyridinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (178); 4,6-Bis(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (179); 6-(3-Bromophenyl)-4-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (180); 3-(3-Amino-4-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzonitrile (181); (3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)acetic acid (182); 2-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)acetohydrazide (183); 6-(2-(4-Morpholinyl)-2-oxoethyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (184); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzamide (185); 5-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-methoxybenzoic acid (186); Benzyl 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1-piperidinecarboxylate (187); Benzyl 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1-piperidinecarboxylate (188); 5-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)nicotinonitrile (189); 5-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)nicotinic acid (190); 4-(4-Phenoxyphenyl)-6-(5-(1H-tetrazol-5-yl)-3-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (191); Methyl 4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoate (192); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (193); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzohydrazide (194); (4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)methanol (195); tert-Butyl N-(4-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoyl)glycinate (196); 6-(4-(4-Morpholinylcarbonyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (197); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-(2-hydroxyethyl)benzamide (198); 6-(4-Aminophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (199); 1-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)-3-phenylurea (201); 1-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)-3-methylurea (203); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)hydrazinecarboxamide (204); 4-(4-Phenoxyphenyl)-6-phenyl-1H-pyrazolo[4,3-c]pyridin-3-amine (205); 6-(4-Aminophenyl)-4-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (206); Methyl 3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoate (207); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (208); 4-(4-Methoxyphenyl)-6-(3-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (209); 4-(3-Amino-6-(3-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-4-yl)phenol (210); 6-(3-Aminophenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (211); 1-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)-3-phenylurea (212); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-cyclopropylbenzamide (213); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-(methylsulfonyl)benzamide (214); 4,6-Diphenyl-1H-pyrazolo[4,3-c]pyridin-3-amine (215); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-methylbenzamide (216); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-1H-tetrazol-5-ylbenzamide (217); (3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl)methanol (218); N-(4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoyl)glycine (219); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-1,3,4-thiadiazol-2-ylbenzamide (220); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzonitrile (221); 4-(4-Phenoxyphenyl)-6-(3-(1H-tetrazol-5-yl)phenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (222); 4-(4-Phenoxyphenyl)-6-(4-(1H-tetrazol-5-yl)phenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (223); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzamide (224); 4-(4-Phenoxyphenyl)-7-(2-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (225); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-7-yl)benzohydrazide (226); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-7-yl)benzoic acid (227); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-7-yl)-N,N-dimethylbenzamide (228); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-7-yl)-N-benzylbenzamide (229); 74344-Morpholinylcarbonyl)phenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (230); 2-(3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)phenyl) acetohydrazide (231); (2-(3-Amino-6-(3-pyridinyl)-1H-pyrazolo[4,3-c]pyridin-4-yl)-5-methoxyphenyl)methanol (232); 4-(4-Phenoxyphenyl)-6-(3-piperidinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (233); 6-(1-Methyl-3-piperidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (234); 6-(1-Benzoyl-3-piperidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (235); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-phenyl-1-piperidinecarboxamide (236); 6-(1-Acryloyl-3-piperidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (237); Methyl(3-(3-amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1-piperidinyl)(oxo) acetate (238); (3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1-piperidinyl)(oxo)acetic acid (239); 4-(4-Phenoxyphenyl)-6-(4-piperidinyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (240); 6-(1-Benzoyl-4-piperidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (241); 4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-N-phenyl-1-piperidinecarboxamide (242); 3-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1-pyrrolidinecarbaldehyde (243); 6-(1-Benzoyl-3-pyrrolidinyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-3-amine (244);
4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-fluorobenzoic acid (245); (4-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-1H-pyrazol-1-yl)acetic acid (246); 5-(3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)-2-thiophenecarboxylic acid (247); (3-((3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-1H-pyrazol-1-yl)acetic acid (248); 2-(3-((3-Amino-4-(4-phenoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)amino)-1H-pyrazol-1-yl)-N,N-dimethylacetamide (259); 4-(3-Amino-4-(6-methoxy-2-naphthyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (260); 4-(3-Amino-4-dibenzo[b,d]thiophen-2-yl-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (251); 4-(3-Amino-4-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (252); 4-(3-Amino-4-phenyl-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (253); 4-(3-Amino-4-(4-ethoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (254); 4-(3-Amino-4-(4-isopropoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (255); 4-(3-Amino-4-(4-(methylsulfanyl)phenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (256); 4-(3-Amino-4-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (257); 4-(3-Amino-4-(2-naphthyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (258); 4-(3-Amino-4-(3-furyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (259); 4-(3-Amino-4-(3-thienyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (260); 4-(3-Amino-4-(1H-pyrazol-3-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (261); 4-(3-Amino-4-(4-(3-fluorophenoxy)phenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (262); or 4-(3-Amino-4-(4-hydroxyphenyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)benzoic acid (263).
16. The compound according to claim 10 or a pharmaceutically acceptable salt thereof, wherein said compound is: 6-Chloro-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (114); 4-(4-Phenoxyphenyl)-6-phenyl-1H-pyrazolo[3,4-d]pyrimidin-3-amine (115); 6-(4-Ethoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (116); 6-(3-Methoxyphenyl)-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (117); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (118); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (119); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (120); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (121); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (122); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (123); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (124); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (125); 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (126); or 6-tert-Butyl-4-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-3-amine (127).