Process for the preparation of hydroquinones
The invention relates to a process for the preparation of a hydroquinone compound of formula (I) wherein R2, R3, R5 and R6 have the meaning according to claim 1 , with the steps of formylating a substituted phenol and oxidizing the resulting substituted 4-hydroxy-benzaldehyde under acidic conditions to the corresponding hydroquinone of formula (I). Another object of the invention concerns the intermediate 2,3,5-trimethyl-4-hydroxy-benzaldehyde for synthesis of 2,3,5-trimethyl-hydroquinone (TMHQ) and (dl)α-tocopherol.
1. A process for the preparation of 2,3,5-trimethylbenzene-1,4-diol, comprising the steps of:
(a) heating to reflux temperature 2,3,6-trimethyl-phenol with 0.3 to 0.4 equivalents of hexamethylenetetramine in an organic acid, followed by adding a hydrolysis medium, which is an aqueous acid, and heating the resulting mixture to yield 2,3,5-trimethyl-4-hydroxy-benzaldehyde, and
(b) reacting 2,3,5-trimethyl-4-hydroxy-benzaldehyde with an oxidizing agent in a solvent under acidic conditions to yield 2,3,5-trimethylbenzene-1,4-diol.
2. The process according to claim 1 , wherein in step (a) the organic acid is glacial acetic acid.
3. The process according to claim 1 , wherein in step (a) the heating is performed at reflux temperature of 90° C. to 135° C., or in step (b) the reaction is performed at a temperature between 15° C. and 50° C.
4. The process according to claim 1 , wherein in step (b) the oxidizing agent is hydrogen peroxide, or the solvent is an alcohol.
5. The process according to claim 1 , wherein in step (b) the acidic conditions are provided by sulfuric acid in a molar ratio to 2,3,5-trimethyl-4-hydroxy-benzaldehyde from 0.1 to 0.3.
6. The process according to claim 1 , wherein prior to step (b), 2,3,5-trimethyl-4-hydroxy-benzaldehyde is purified with sodium hydroxide in a molar ratio of 2,3,5-trimethyl-4-hydroxy-benzaldehyde to sodium hydroxide from 0.2 to 5.
7. The process according to claim 1 , wherein after step (b), 2,3,5-trimethylbenzene-1,4-diol is purified with a reducing agent.
8. The process according to claim 1 , wherein said hydrolysis medium is sulfuric acid.
9. The process according to claim 3 , wherein said reflux temperature is in the range of 110° C. to 130° C.
10. The process according to claim 5 , wherein said molar ratio is 0.2.
11. A process for the preparation of 2,6-diethylbenzene-1,4-diol, comprising the steps of:
(a) heating to reflux temperature 2,6-diethyl-phenol with 0.3 to 0.4 equivalents of hexamethylenetetramine in an organic acid, followed by adding a hydrolysis medium, which is an aqueous acid, and heating the resulting mixture to yield 3,5-diethyl-4-hydroxy-benzaldehyde, and
(b) reacting 3,5-diethyl-4-hydroxy-benzaldehyde with an oxidizing agent in a solvent under acidic conditions to yield 2,6-diethylbenzene-1,4-diol.
12. The process according to claim 11 , wherein in step (a) the organic acid is glacial acetic acid.
13. The process according to claim 11 , wherein in step (a) the heating is performed at reflux temperature of 90° C. to 135° C., or in step (b) the reaction is performed at a temperature between 15° C. and 50° C.
14. The process according to claim 11 , wherein in step (b) the oxidizing agent is hydrogen peroxide, or the solvent is an alcohol.
15. The process according to claim 11 , wherein in step (b) the acidic conditions are provided by sulfuric acid in a molar ratio to 3,5-diethyl-4-hydroxy-benzaldehyde from 0.1 to 0.3.
16. The process according to claim 11 , wherein prior to step (b), 3,5-diethyl-4-hydroxy-benzaldehyde is purified with sodium hydroxide in a molar ratio of 3,5-diethyl-4-hydroxy-benzaldehyde to sodium hydroxide from 0.2 to 5.
17. The process according to claim 11 , wherein after step (b), 2,6-diethylbenzene-1,4-diol is purified with a reducing agent.
18. The process according to claim 11 , wherein said hydrolysis medium is sulfuric acid.
19. The process according to claim 13 , wherein said reflux temperature is in the range of 110° C. to 130° C.
20. The process according to claim 15 , wherein said molar ratio is 0.2.