Compositions and methods for the therapy and diagnosis of cytomegalovirus infections
The present invention provides anti-cytomegalovirus antibodies and related compositions and methods. These antibodies may be used in the diagnosis, prevention, and treatment of cytomegalovirus infection.
1. A method for the treatment of a CMV infection in a subject, comprising administering to the subject a composition comprising an isolated anti-CMV antibody, or antigen-binding fragment thereof, wherein said antibody comprises:
(a) a V H region comprising
(i) a V H CDR1 region comprising the amino acid sequence of SSNGIH (SEQ ID NO: 57);
(ii) a V H CDR2 region comprising the amino acid sequence of VISSDANDKQYADSVKG (SEQ ID NO: 58); and
(iii) a V H CDR3 region comprising the amino acid sequence of DGTCSGGNCYSGLIDY (SEQ ID NO: 59); and
(b) a V L region comprising
(i) a V L CDR1 region comprising the amino acid sequence of RASQSVGGYLA (SEQ ID NO: 43);
(ii) a V L CDR2 region comprising the amino acid sequence of ASIRAT (SEQ ID NO: 64); and
(iii) a V L CDR3 region comprising the amino acid sequence of HQRSNWPPLT (SEQ ID NO: 65).
2. The method of claim 1 , wherein the method further comprises administering an anti-viral treatment.
3. The method of claim 2 , wherein said anti-viral treatment is ganciclovir, foscarnet, cidofovir, valganciclovir, or intravenous immunoglobulin (IVIG).
4. The method of claim 1 , wherein said antibody is administered at a dose sufficient to neutralize CMV infection.