Surgical sutures incorporated with stem cells or other bioactive materials
Materials and methods for immobilizing bioactive molecules, stem and other precursor cells, and other agents of therapeutic value in surgical sutures and other tissue scaffold devices are described herein. Broadly drawn to the integration and incorporation of bioactive materials into suture constructs, tissue scaffolds and medical devices, the present invention has particular utility in the development of novel systems that enable medical personnel performing surgical and other medical procedures to utilize and subsequently reintroduce bioactive materials extracted from a patient (or their allogenic equivalents) to a wound or target surgical site.
1. A surgical suture comprising:
(a) a porous core comprising a multifilament or a matrix of braided or woven filaments comprising a plurality of interstices disposed between the filaments; and
(b) a sheath which is exterior to the porous core and comprises one or more concentric layers;
wherein a concentration of biological cells are retained in the plurality of interstices; and wherein the sheath controls the migration of the biological cells from the plurality of interstices to an exterior of the sheath.
2. The surgical suture of claim 1 , wherein the sheath comprises a porous, braided, or woven structure.
3. The surgical suture of claim 1 , wherein the biological cells are retained in the plurality of interstices by ionic binding, covalent binding, adsorption, absorption, entrapment, entanglement, or entrainment, or combinations thereof.
4. The surgical suture of claim 1 , wherein the sheath further comprises a biodegradable component that impedes or forestalls an exodus of the biological cells until the surgical suture is placed in a target biological environment.
5. The surgical suture of claim 1 , wherein the porous core comprises a viscous liquid, foam, gel, or emulsion containing the biological cells that is bound, absorbed, adsorbed or immobilized by the multifilament or matrix of braided or woven filaments.
6. The surgical suture of claim 1 , wherein the sheath comprises a porous, braided, woven, non-woven, or film-type construct in combination with an emulsion, suspension, liquid, or gel.
7. The surgical suture of claim 6 , wherein the emulsion, suspension, liquid, or gel exhibits hydrophobic properties.
8. The surgical suture of claim 1 , wherein the surgical suture further comprises a bearing section and a contiguous leader section, and wherein the bearing section comprises a length of a suture material comprising a therapeutically effective level of biological cells.
9. The surgical suture of claim 8 , wherein the leader section is visibly differentiable from the bearing section by a change in color, texture, or shape.
10. The surgical suture of claim 1 , wherein the biological cells are selected from the group consisting of stem cells, progenitor cells, and precursor cells.
11. The surgical suture of claim 1 , wherein the porous core comprises a material that is biodegradable.