Antiparkinsonian action of phenylisopropylamines
A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
1. A method of treating a subject for Parkinson's disease comprising: administering to said subject in need thereof synergistic effective amounts of L-DOPA in combination with 3,4 methylenedioxymethamghetamine (MDMA) or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein said MDMA is (±)-3,4 methylenedioxymethamphetamine ((±)-MDMA).
3. The method of claim 1 , wherein said MDMA is (+)-3,4 methylenedioxymethamphetamine ((+)-MDMA).
4. The method of claim 1 , wherein said L-DOPA is administered in combination with carbidopa.
5. The method of claim 1 , wherein said treating comprises treating at least one motor symptom of Parkinson's disease.
6. The method of claim 1 , wherein said Parkinson's disease is early onset Parkinson's disease.
7. The method of claim 1 , wherein said Parkinson's disease is late stage Parkinson's disease.
8. The method of claim 1 , wherein said subject is a human subject.
9. A method of treating a human subject in need thereof for Parkinson's disease comprising:
administering to said subject L-DOPA in combination with carbidopa, and
administering to said subject 3,4 methylenedioxymethamphetamine (MDMA) or a pharmaceutically acceptable salt thereof, said MDMA administered in combination with said L-DOPA in an amount effective to synergistically enhance the efficacy of said L-DOPA.
10. The method of claim 9 , wherein said MDMA is (±)-3,4 methylenedioxymethamphetamine ((±)-MDMA).
11. The method of claim 9 , wherein said MDMA is (+)-3,4 methylenedioxymethamphetamine ((+)-MDMA).
12. The method of claim 9 , wherein said treating comprises treating at least one motor symptom of Parkinson's disease.
13. The method of claim 9 , wherein said Parkinson's disease is early onset Parkinson's disease.
14. The method of claim 9 , wherein said Parkinson's disease is late stage Parkinson's disease.