Compositions and methods for tissue repair
The present invention provides compositions and methods for targeting an extracellular matrix derived (EMD) peptide predominantly to an injured tissue, as opposed to an uninjured tissue in vivo. The targeted EMD peptide facilitates the repair and/or regeneration of the injured tissue by providing a surface for cells to attach and grow, thereby facilitating the repair and/or regeneration of the injured tissue.
1. A composition for repair of an injured tissue, the composition comprising
an injury-associated antigen-specific binding component conjugated to an extracellular matrix derived (EMD) peptide,
wherein the injury-associated antigen-specific binding component is an antibody that specifically binds myosin heavy chain and
wherein the EMD peptide comprises a Hep III peptide comprising the sequence of SEQ ID NO:2, and exhibits the ability to: (i) activate cells; (ii) attach cells; and (iii) exhibits a chemotropic property.
2. The composition of claim 1 , wherein the EMD peptide further exhibits an angiogenic property.
3. The composition of claim 1 , wherein the injury-associated antigen-specific binding component and the EMD peptide are chemically or recombinantly conjugated.
4. The composition of claim 1 , wherein the antibody is selected from the group consisting of a (Fab)′2 fragment, an ScFv, a human antibody, and a humanized antibody.
5. The composition of claim 1 , further comprising a pharmaceutically acceptable excipient.