Granted Patent
B2
US 8,889,877 · App. 13/636,237 · Granted Nov 18, 2014
Processes for preparing pyridinone carboxylic acid aldehydes
Inventors:
Steven N. Goodman (King of Prussia, PA); Matthew David Kowalski (King of Prussia, PA); Douglas Matthew Mans (King of Prussia, PA); Huan Wang (King of Prussia, PA)
Assignee:
VIIV Healthcare Company
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Abstract
The present invention relates to the preparation of pyridinone carboxylic acid aldehydes such as 5-methoxy-6-(methoxycarbonyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-3-carboxylic acid.
Claims (11)
1. A process for the preparation of a compound of formula (V)
wherein R is alkyl, aryl, or benzyl,
comprising hydrolyzing a compound of formula (III)
wherein R is alkyl, aryl, or benzyl,
in the presence of lithium hydroxide to form a compound of formula (IV)
wherein R is alkyl, aryl, or benzyl.
2. A process for the preparation of a compound of formula (V)
wherein R is alkyl, aryl or benzyl,
comprising contacting a compound of formula (IV)
wherein R is alkyl, aryl, or benzyl,
with acetic acid and a catalytic amount of a strong protic acid.
Continuity (2)
Provisional Application
61316421
· Mar 23, 2010