Wound healing compositions including cyanoacrylate monomers and phenytoin
A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
1. A monomeric adhesive composition comprising: an alpha cyanoacrylate monomer, an amount of butylated hydroxyl anisole and sulfur dioxide effective to stabilize the alpha cyanoacrylate monomer, and 0.05% to 0.3% by weight of the composition of phenytoin; wherein the composition is a homogeneous mixture.
2. The composition of claim 1 , wherein said composition is sterilized, and the viscosity of the sterilized composition increases between about 0% and about 40% after sterilization relative to the viscosity of the composition prior to sterilization.
3. A kit, an applicator and the composition of claim 1 .
4. A method of treating tissue comprising applying the adhesive composition of claim 1 to a tissue surface, and allowing said composition to polymerize on said tissue surface.
5. The monomeric adhesive composition of claim 1 , further comprising a polymerization accelerator.
6. The monomeric adhesive composition of claim 1 , further comprising a plasticizing agent.
7. The monomeric adhesive composition of claim 1 , further comprising a thickening agent.
8. The monomeric adhesive composition of claim 1 , wherein the composition is sterilized by irradiation.
9. The monomeric adhesive composition of claim 8 , wherein the composition is sterilized by E-beam irradiation.
10. The monomeric adhesive composition of claim 1 , wherein the composition comprises 2-octyl cyanoacrylate monomer and an amount of butylated hydroxyl anisole and sulfur dioxide effective to stabilize the 2-octyl cyanoacrylate monomer, homogenously mixed together with 0.1% to 0.2% by weight of the composition of phenytoin.
11. The monomeric adhesive composition of claim 1 , wherein the cyanoacrylate monomer is selected from the group consisting of 2-octyl cyanoacrylate, n-butyl cyanoacrylate, and a mixture that is 80% by weight 2-octyl cyanoacrylate and 20% by weight n-butyl cyanoacrylate.
12. The monomeric adhesive composition of claim 1 , wherein the composition comprises 0.1% to 0.2% by weight of the composition of phenytoin.
13. A method for preparing the composition of claim 1 , comprising mixing 0.05% to 0.3% by weight of the composition of phenytoin together with alpha cyanoacrylate monomer stabilized with an amount of butylated hydroxyl anisole and sulfur dioxide effective to stabilize the alpha cyanoacrylate monomer at a temperature of about 60 degrees C. to about 90 degrees C. for a period of time sufficient to dissolve the phenytoin and form a homogeneous mixture, and allowing the mixture to cool, and optionally, sterilizing the composition.