IP Library › Granted Patent US 8,900,549
Granted Patent B2
US 8,900,549 · App. 13/126,660 · Granted Dec 2, 2014

Compositions and methods for delivering a substance to a biological target

Inventors: Scott A. Hilderbrand (Swampscott, MA); Neal K. Devaraj (Boston, MA); Ralph Weissleder (Charlestown, MA)
Assignee: The General Hospital Corporation
G01N33/5306A61K51/0474B82Y5/00A61K49/0041A61K49/0019A61K47/4813G01N33/532A61K51/0495A61K47/48746
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Quick Facts
Patent No.
US 8,900,549
App. No.
13/126,660
Granted
Dec 2, 2014
Kind
B2
Abstract

The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.

Claims (2)

1. A compound selected from the group consisting of

2. A composition comprising a compound selected from the group consisting of

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 12, 2013
From: THE GENERAL HOSPITAL CORPORATION
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031208/0245 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2011
From: HILDERBRAND, SCOTT A.; DEVARAJ, NEAL K.; WEISSLEDER, RALPH
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 026553/0433 →
Continuity (2)
Provisional Application 61110121 · Oct 31, 2008
Related Publication 20110268654A1 · Nov 3, 2011