Injector apparatus and method for drug delivery
Methods and apparatus provide a therapeutic fluid to devices implanted in the body, for example to containers of devices implanted in the eye of a patient. The methods and apparatus may comprise an injector to increase an amount of therapeutic agent injected into the device implanted in the eye, or a structure to receive the therapeutic fluid within the device implanted in the eye, or combinations thereof. The device implanted in the eye may comprise a reservoir chamber having a fluid with a density different than the therapeutic fluid, and the apparatus can be adapted to at least partially separate the implanted device fluid from therapeutic fluid within the reservoir chamber to increase and amount of therapeutic fluid placed in the reservoir chamber.
1. A system for injecting a therapeutic agent into an ocular implant, the ocular implant being at least partially implanted in an eye, the system comprising:
an injection lumen configured to provide a pathway for injecting a therapeutic agent into the ocular implant, the injection lumen having an outlet opening for therapeutic agent to flow out of the injection lumen into the implant;
an outlet lumen configured to provide a pathway through which pre-existing fluid in the ocular implant exits the ocular implant as therapeutic agent is injected into the ocular implant through the injection lumen, wherein the outlet lumen surrounds at least a portion of the injection lumen, the outlet lumen having an inlet opening for fluid to exit into the outlet lumen from the ocular implant;
a receiver chamber fluidly coupled to the outlet lumen, the receiver chamber configured to receive fluid that exits the ocular implant via the outlet lumen;
wherein injection of the therapeutic agent into the ocular implant via the injection lumen displaces pre-existing fluid in the ocular implant into the receiver chamber via the outlet lumen, and wherein the injection lumen is in a fixed position relative to the outlet lumen.
2. A system as in claim 1 , further comprising a needle that defines the injection lumen.
3. A system as in claim 2 , further comprising a sheath positioned at least partially over the needle so as to form the outlet lumen between an inner surface of the sheath and an outer surface of the needle.
4. A system as in claim 1 , wherein the outlet lumen and the injection lumen are concentrically positioned relative to one another.
5. A system as in claim 1 , further comprising a source chamber fluidly coupled to the injection lumen, the source chamber providing a source of therapeutic agent for injecting into the ocular implant via the injection lumen.
6. A system as in claim 5 , wherein the source chamber is removably attached to the injection lumen.
7. A system as in claim 5 , wherein the source chamber is loaded with a therapeutic agent.
8. A system as in claim 5 , wherein the source chamber is part of a syringe that attaches to the injection lumen.
9. A system as in claim 1 , further comprising a hub configured to removably receive a syringe that is configured to fluidly couple to the injection lumen.
10. A system as in claim 3 , wherein the sheath forms the inlet opening through which fluid can pass from the implant into the outlet lumen.
11. A system as in claim 10 , wherein the inlet opening is between a distal-most end of the sheath and an outer surface of the needle.
12. A system as in claim 2 , wherein the outlet opening is an opening at the end of the needle that permits fluid to pass from the injection lumen into the ocular implant.
13. A system as in claim 3 , wherein the opening at the end of the needle is distal of an opening into the outlet lumen.
14. A system as in claim 1 , wherein the system further comprising a stop, the stop configured to limit a depth of insertion of the injection lumen into the ocular implant.
15. A system as in claim 3 , wherein a distal tip of the sheath tapers such that at least a portion of the distal tip of the sheath contacts an outer surface of the needle.
16. A system as in claim 3 , wherein at least a portion of a distal tip of the sheath is spaced from an outer surface of the needle.
17. A system as in claim 1 , wherein the outlet opening of the injection lumen is distal of the inlet opening of the outlet lumen during injection of the therapeutic agent into the ocular implant.
18. A system as in claim 1 , wherein the outlet opening of the injection lumen is in a fixed position relative to the inlet opening of the outlet lumen.