Treatment for meibomian gland dysfunction or obstruction
A jojoba formulation has been developed for administration to the meibomian gland, for treatment of the symptoms of dry eye, and/or for drug delivery to the meibomian gland. The formulation incorporates the natural product jojoba wax, or components thereof, to enhance the spreading of the artificial tear as well as stabilize the tear film. The jojoba wax tear relieves irritation and discomfort as well as sharpens the blurred vision. Jojoba, because of its close chemical and physical properties to meibomian gland secretions, is effective upon topical application to penetrate the lid margin to reach the gland tissues where it may exert a therapeutic effect with or without an adjunctive agent.
1. A method of treating obstructed or dysfunctional meibomian glands comprising applying an effective amount of a jojoba wax formulation to penetrate the lid margin and reduce meibomian gland obstruction.
2. The method of claim 1 comprising applying an ointment comprising an effective amount of jojoba wax or derivative thereof, or a component thereof.
3. The method of claim 2 wherein the component is a wax ester and/or alcohol esterified with long chain fatty acids with a total of 12 to 62 carbon atoms.
4. The method of claim 1 comprising a jojoba concentration from 5% to 50% by weight of the formulation.
5. The method of claim 1 comprising applying a semi-solid ointment or cream, wherein the ointment or cream base is a semi-solid selected from the group consisting of a mixture of mineral oil and petrolatum in a ratio of about 70% to 30%, paraffin up to 5% by weight of the ointment or cream base, white ointment up to 100% of the ointment or cream base, white petrolatum up to 100% by weight of the ointment or cream base, petrolatum up to 100% by weight of the ointment or cream base, white wax up to 5% of the ointment or cream base, yellow wax up to 5% by weight of the ointment or cream base, mineral oil up to 50% by weight of the ointment or cream base, light mineral oil up to 50% by weight of the ointment or cream base, lanolin 1 to 10% by weight of the ointment or cream base, and anhydrous lanolin 1 to 10% by weight of the ointment or cream base.
6. The method of claim 1 wherein the formulation comprises a local anesthetic.
7. The method of claim 6 wherein the formulation comprises from 2 to 20% Lidocaine by weight of the formulation.
8. The method of claim 2 wherein the formulation comprises 8% lidocaine and 25% Jojoba by weight of the ointment in a petrolatum ointment base.
9. The method of claim 1 comprising administering the formulation to the lid margin to unblock the modified sebaceous glands of the eyelid known as meibomian glands.
10. The method of claim 1 to provide relief wherein the patient has meibomian gland dysfunction.
11. The method of claim 1 , wherein the effective amount of a jojoba wax formulation comprises a combination of jojoba wax and jojoba wax ester and/or alcohol esterified with long chain fatty acids with a total of 12 to 62 carbon atoms.