Anaesthetic formulation
The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.
1. A formulation comprising a neuroactive steroid anaesthetic formulated with a cyclodextrin, wherein the neuroactive steroid anaesthetic is selected from the group consisting of alphadolone, allopregnanolone, ganaxolone, pregnanolone, acebrochol, hydroxydione, minaxolone and tetrahydroxy corticosterone, or a deuterated, tritiated or labelled derivative or salt thereof, and wherein the cyclodextrin is (7) sulfobutyl ether β-cyclodextrin or an alkyl ether derivative thereof and wherein the molar ratio of neuroactive steroid anaesthetic to cyclodextrin is from 1:1.6 to 1:2.5 except for alphadolone where the complexation ratio is from 1:2 to 1:2.5.
2. The formulation of claim 1 wherein the molar ratio of neuroactive steroid anaesthetic to cyclodextrin is from 1:2 to 1:2.5.
3. The formulation of claim 1 further comprising one or more of an antimicrobial agent, a preservative, a buffer and/or a co-polymer.
4. The formulation of claim 3 wherein the formulation comprises a co-polymer selected from the group consisting of hydroxy propyl methyl cellulose, polyvinyl pyrollidone and carboxymethyl cellulose.
5. The formulation of claim 3 wherein the formulation comprises a buffer, and the pH is from about pH 5.5 to about pH 8.
6. The formulation of claim 1 wherein the formulation comprises a derivative, wherein the derivative is sulfobutyl ether-alkyl ether cyclodextrin.
7. The formulation of claim 6 wherein the cyclodextrin is sulfobutyl ether-ethyl ether, β-cyclodextrin or its sodium salt.
8. A method of treating a human subject comprising administering the formulation of claim 1 to said human subject.
9. A method of inducing anaesthesia or sedation in a human subject, said method comprising administering an effective amount of a formulation of claim 1 to said human subject.