IP Library › Granted Patent US 8,983,166
Granted Patent B2
US 8,983,166 · App. 13/427,251 · Granted Mar 17, 2015

Method for automatically seeding previously-classified images among images of objects of interest from a specimen

Inventor: Howard B. Kaufman (Newton, MA)
Assignee: Hologic, Inc.
G06F19/321G06F19/327G06F19/345G06F19/366G06K9/6263G06K9/00127G06K9/033
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Quick Facts
Patent No.
US 8,983,166
App. No.
13/427,251
Granted
Mar 17, 2015
Kind
B2
Abstract

A computer-assisted method of classifying cytological samples, includes using a processor to analyze images of cytological samples and identify cytological objects of interest within the sample images, wherein the processor (i) displays images of identified cytological objects of interest from the sample images to a reviewer, (ii) accesses a database of images of previously classified cytological objects, and (iii) displays to the reviewer, interspersed with the displayed images of the identified objects of interest from the sample images, one or more images obtained from the database of images of previously-classified objects.

Claims (11)

1. A computer-assisted method of classifying cytological samples, comprising:

using one or more processors to

display previously unclassified cytological sample images to a reviewer,

receive classifications of the displayed cytological sample images from the reviewer,

monitor a reviewer classification rate equal to a number of displayed previously unclassified cytological sample images receiving a specified classification by the reviewer divided by a total number of previously unclassified cytological sample images displayed to the reviewer, and

if the monitored reviewer classification rate is below a threshold rate, display to the reviewer, interspersed with the displayed previously unclassified cytological sample images, one or more images of the specified classification obtained from a database of images of previously classified cytological samples.

2. The method of claim 1 , wherein the specified classification indicates that the image includes abnormal cytological objects.

3. The method of claim 1 , wherein the one or more processors

receive reviewer determined classifications of the displayed images obtained from the database of images of previously classified cytological samples; and

determine a percentage of said reviewer determined classifications that indicate said displayed images are of the specified classification.

4. The method of claim 1 , wherein displaying the previously unclassified cytological sample images to a reviewer comprises displaying images of fields of view of respective cytological samples, each field of view image having one or more previously identified objects of interest therein.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
SECURITY INTEREST Recorded Apr 8, 2026
From: BIOTHERANOSTICS, INC.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; CYTYC CORPORATION; SUROS SURGICAL SYSTEMS, INC.; GYNESONICS, INC.; BOLDER SURGICAL, LLC; FAXITRON BIOPTICS, LLC; HEALTH BEACONS, INC.; HOLOGIC, INC.
To: ROYAL BANK OF CANADA, AS COLLATERAL AGENT
Reel/Frame 075462/0440 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 22, 2012
From: KAUFMAN, HOWARD B.
To: HOLOGIC, INC.
Reel/Frame 027911/0195 →
Continuity (2)
Provisional Application 61466856 · Mar 23, 2011
Related Publication 20120243755A1 · Sep 27, 2012