Pyrrolo[2,3-D]pyrimidine compounds
Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds.
1. A method for treating allergic reactions, allergic dermatitis, atopic dermatitis, eczema, or pruritus in a mammal comprising administering to a mammal in need a therapeutically effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof wherein R 1 is C 1-4 alkyl optionally substituted with hydroxy.
2. The method of claim 1 wherein the therapeutically effective amount is from 0.01 mg/kg of body weight/day to 100 mg/kg of body weight/day.
3. The method of claim 1 wherein the therapeutically effective amount is from 0.1 mg/kg of body weight/day to 10 mg/kg of body weight/day.
4. The method of claim 1 wherein the mammal comprises companion animals.
5. The method of claim 4 wherein the companion animals are dogs.
6. The method of claim 1 wherein the mammal comprises livestock.
7. The method of claim 1 wherein the compound of formula I is administered orally, parenterally, or topically.