Method of preparing a swallowable capsule comprising a sensor
A kit includes a swallowable capsule ( 1, 45 ) with a potentiometric sensor ( 3 ), such as a pH sensor, with an unfilled electrolyte cell ( 31 ). The kit further includes a separate container ( 46 ) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell ( 31 ) is filled with the electrolyte.
1. A kit comprising:
a capsule comprising a potentiometric sensor with an unfilled electrolyte cell;
a liquid electrolyte container containing a liquid electrolyte; and
one or more buffer liquid containers containing buffer liquids for calibration, wherein the capsule, the liquid electrolyte container and the buffer liquid containers are contained in separated portions of a single package configured to be received in at least one opening of a start-up station.
2. The kit according to claim 1 wherein the potentiometric sensor is a pH sensor.
3. The kit according to claim 1 wherein the capsule and the electrolyte container are separately packed in a single blister packing.
4. A method of preparing a swallowable capsule comprising a potentiometric sensor having an electrolyte cell, the method comprising:
providing a single packing comprising, the swallowable capsule, a liquid electrolyte container containing a liquid electrolyte, and a buffer liquid container containing a buffer liquid, wherein the swallowable capsule, the liquid electrolyte container, and the buffer liquid container are separated within the single packing;
placing at least a portion of the single packing in an opening of a startup station; and
in response to placing the at least the portion of the single packing in the opening of the startup station, with the single packing being retained in the startup station, causing the liquid electrolyte to fill the electrolyte cell.
5. The method according to claim 4 further comprising activating the capsule with the startup station after filling the electrolyte cell.
6. The method according to claim 5 further comprising calibrating the capsule by contacting the electrolyte in the electrolyte cell with a buffer liquid.
7. The method Method according to claim 6 wherein the calibrating is repeated for one or more additional buffer liquids.
8. A start-up station for use in a method according to claim 4 wherein the start-up station comprises at least two openings for receiving a capsule, wherein at least one of the openings is within the scope of electro-inductive control circuitry for activating the capsule and at least one of the openings is an opening for containing the liquid electrolyte, the opening being dimensioned to receive the capsule leaving one or more venting openings free.
9. The start-up station according to claim 8 wherein the electrolyte filled opening forms the piston chamber of a piston opposite the open end of the opening, the open end being provided with a sealing ring.
10. The start-up station according to claim 9 wherein the station comprises one or more further openings at least partly filled with respective buffer liquids.