Preservation of cosmetics, toiletry and pharmaceutical compositions
A composition for and methods of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological contamination or growth are described in which the compositions used herein include at least one hydroxamic acid, salt or complex thereof, and the methods include addition of an effective amount of such compounds to a cosmetic, toiletry or pharmaceutical formulation. Compositions further including alkanediols and/or solubilizing agents in blends with hydroxamic acid are also described.
1. A method of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological growth comprising adding an effective amount of a blend consisting of at least one hydroxamic acid, or a salt and/or a complex thereof and a diol, wherein the formulation is preserved against microbiological growth over time.
2. The method according to claim 1 , wherein the at least one hydroxamic acid comprises an alkylhydroxamic acid.
3. The method according to claim 1 , wherein the alkylhydroxamic acid comprises a linear or branched, saturated or unsaturated, substituted or unsubstituted, carbon chain of two to about twenty-two carbon atoms.
4. The method according to claim 1 , wherein the alkylhydroxamic acid comprises a linear carbon chain of about six to about twelve carbon atoms.
5. The method according to claim 1 , wherein the at least one alkylhydroxamic acid is selected from the group consisting of hexanohydroxamic acid, caprylohydroxamic acid, caprohydroxamic acid, laurohydroxamic acid and mixtures and combinations thereof.
6. The method according to claim 5 , wherein the alkylhydroxamic acid is caprylohydroxamic acid.
7. The method according to claim 1 wherein the at least one diol is a vicinal diol.
8. The method according to claim 7 , wherein the at least one vicinal diol is a 1,2-alkanediol.
9. The method according to claim 8 , wherein the at least one 1,2-alkanediol is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol and mixtures and combinations thereof.
10. The method according to claim 7 , wherein the at least one vicinal diol is a glyceryl monoester and/or a glyceryl monoether.
11. The method according to claim 10 , wherein the at least one glyceryl monoester is selected from the group consisting of glyceryl monocaprate, glyceryl mono caproate, and glyceryl monocaprylate.
12. The method according to claim 7 , wherein the at least one glyceryl monoether is ethylhexyl glycerine.
13. A method of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological growth comprising adding an effective amount of a blend consisting of at least one hydroxamic acid, or a salt and/or a complex thereof and a diol, wherein the formulation is parabens free and is preserved against microbiological growth over time.
14. The method according to claim 13 , wherein the at least one hydroxamic acid comprises an alkylhydroxamic acid.
15. The method according to claim 13 , wherein the alkylhydroxamic acid comprises a linear or branched, saturated or unsaturated, substituted or unsubstituted, carbon chain of two to about twenty-two carbon atoms.
16. The method according to claim 13 , wherein the at least one alkylhydroxamic acid is selected from the group consisting of hexanohydroxamic acid, caprylohydroxamic acid, caprohydroxamic acid, laurohydroxamic acid and mixtures and combinations thereof.
17. The method according to claim 13 , wherein the at least one diol is a vicinal diol.
18. The method according to claim 17 , wherein the at least one vicinal diol is a 1,2-alkanediol.
19. A method of preserving a topical cosmetic, toiletry or pharmaceutical formulation against microbiological growth comprising adding an effective amount of a blend consisting of at least one hydroxamic acid, or a salt and/or a complex thereof, an aromatic alcohol and a diol, wherein the formulation is preserved against microbiological contamination and growth over time.
20. The method according to claim 19 , wherein the at least one hydroxamic acid comprises an alkylhydroxamic acid.
21. The method according to claim 19 , wherein the alkylhydroxamic acid comprises a linear or branched, saturated or unsaturated, substituted or unsubstituted, carbon chain of two to about twenty-two carbon atoms.
22. The method according to claim 19 , wherein the at least one hydroxamic acid is selected from the group consisting of hexanohydroxamic acid, caprylohydroxamic acid, caprohydroxamic acid, laurohydroxamic acid and mixtures and combinations thereof.
23. The method according to claim 19 , wherein the aromatic alcohol is phenoxyethanol.